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Diss Factsheets
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EC number: 225-004-1 | CAS number: 4602-84-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Hydrolysis: The hydrolysis test has been waived as the test substance is readily biodegradable.
Biodegradation in water (screening tests): The test item is readily biodegradable based on the weight of evidence. Over 70% biodegradation has been reported after 28 days in two studies, and a third study demonstrated 51.7% degradation after 28 days. As the substance is a mixture of E and Z isomers, the 10-day window criterion does not apply (EFEO/IFRA Guidelines on the Environmental Assessment of Natural Complex Substances (NCS), 2016).
Adsorption / desorption: Based on a log Kow of 4.72 (weighted average), the Koc was 1332 L/kg and the log Koc was 3.1244. Based on the molecular connectivity index, the Koc was 1666 L/kg and the log Koc was 3.22. Using the mean of the results from the log Kow and MCI method, the Koc was determined to be 1499 L/kg and the log Koc was 3.176.
Henry's Law constant: The Henry's law constant is calculated to be 578 Pa m3/mol at 25°C.
Additional information
Environmental fate endpoints are completed for this substance based on test data following standard guidelines or data waivers. All data are therefore considered to be reliable and relevant for the endpoint concerned.
Hydrolysis: The hydrolysis test has been waived in accordance with section 9 of REACH Annex VIII, as the substance is readily biodegradable.
Biodegradation in water (screening tests): Biodegradation of the test item was determined in the three reliable studies, reporting 51.7 to 80% biodegradation over 28 days (1996, 1997, 2011). According to EFEO/IFRA Guidelines on the Environmental Assessment of Natural Complex Substances (NCS) (2016), "the 10 day window may be waived for a complex multi-constituent substance with structurally similar constituents and only the pass level of 60% at 28 days applied for a readily biodegradability classification". The test item is a mixture of E and Z isomers, therefore the 10-day window criterion does not apply. Considering the weight of evidence, farnesol can be considered to be readily biodegradable.
Adsorption / desorption: The adsorption coefficient has been calculated by QSAR (KOCWIN v2.0) and is considered reliable with restriction (Klimisch 2) for this endpoint as it is within the molecular weight domain and a correction factor is available for a suitable substance structural fragment. Based on a log Kow of 4.72 (weighted average), the Koc was 1332 L/kg and the log Koc was 3.1244. Based on the molecular connectivity index, the Koc was 1666 L/kg and the log Koc was 3.22. Using the mean of the results from the log Kow and MCI method, the Koc was determined to be 1499 L/kg and the log Koc was 3.176.
Henry's Law constant: The Henry's law constant for the test substance was calculated according to ECHA guidance R.16: Environmental exposure assessment (ECHA 2016), using experimental data for water solubility and vapour pressure. The Henry's law constant is calculated to be 578 Pa m3/mol at 25°C. This result is reliable with restrictions (Klimisch 2) as the experimental values were reported from two good quality studies (Klimisch 1).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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