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EC number: 291-350-5 | CAS number: 90387-74-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Glycine, N-coco acyl derivs., sodium salts
- EC Number:
- 291-350-5
- EC Name:
- Glycine, N-coco acyl derivs., sodium salts
- Cas Number:
- 90387-74-9
- Molecular formula:
- Molecular formula for this UVCB is not available.
- IUPAC Name:
- Glycine, N-coco acyl derivs., sodium salts
Constituent 1
- Specific details on test material used for the study:
- Name: Sodium cocoyl glycinate (GCS-12)
Lot No.: 970925
Description: Clear liquid
Composition: 31.5% solution
Storage: Cool, dark place
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- not further specified
Test system
- Vehicle:
- water
- Controls:
- yes, concurrent vehicle
- yes, concurrent positive control
- Amount / concentration applied:
- 0.1 mL of a 5% (w/w) solution
- Duration of treatment / exposure:
- single application / not rinsed
- Observation period (in vivo):
- up to 1 week
- Number of animals or in vitro replicates:
- 6 per group
- Details on study design:
- Prior to application, both eyes of each rabbit were macroscopically examined to select healthy rabbits with eyes that were free from disease and injury in the cornea, iris and conjunctivae. The animals were then assigned to 3 groups: vehicle control (distilled water for injection), test item (5% solution) and positive control (5% SLS solution). On the day of application, each rabbit was restricted using an animal holder, and 0.1 mL of the test solution was applied using a disposable syringe to the right eye by pulling the lower eyelid into a cup-shape. Both eyelids were held together for two to three seconds following application. The left eye was designated the non-treatment control. The cornea, iris, conjunctivae and discharge were evaluated using the Draize scale 24, 48, 72 and 96 hours, and one week following application.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 41.3
- Remarks on result:
- probability of mild irritation
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 7 d
- Score:
- 1
- Remarks on result:
- probability of mild irritation
Applicant's summary and conclusion
- Interpretation of results:
- Category 2B (mildly irritating to eyes) based on GHS criteria
- Conclusions:
- Based on the results of this study it was assessed that a 5% w/w solution of the test item was mildly irritating to rabbit eyes.
- Executive summary:
In a primary eye irritation study with rabbits, the test item was evaluated using the Draize scale and classified using the Kay and Calandra classification criteria. Slight to mild opacity ranging from less than a quarter to the whole of the cornea, congestion in the iris, mild to moderate redness of the conjunctivae, slight to definite swelling, and mild to severe discharge were observed 24 hours following administration of a 5% (w/w) solution. The irritations subsided with time, and the only irritation that was observed one week following administration was mild redness of the conjunctivae, which was observed in three cases. Based on the results of this study it was assessed that a 5% (w/w) solution of the test item was mildly irritating to rabbit eyes.
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