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EC number: 246-758-8 | CAS number: 25251-42-7
Endpoint summary
Administrative data
Description of key information
Biodegradation in water:
Biodegradability of test chemical 4-hydroxy-6-[(3-sulfophenyl)amino]naphthalene-2-sulfonic acid (CAS No: 25251-42-7) is predicted using OECD QSAR tool box v.3.3 using log Kow as primary descriptor. The test chemical 4-hydroxy-6-[(3-sulfophenyl)amino]naphthalene-2-sulfonic acid showed 4.48 % biodegradability by considering BOD as parameter and microorganisms as inoculum in 28 days. Since percent biodegradability is very low it is concluded that this test chemical is not readily biodegradable.
Biodegradation in water and sediments:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 4-hydroxy-6-[(3-sulfophenyl)amino]naphthalene-2-sulfonic acid (CAS No: 25251-42-7). If released in to the environment, 9.59 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of the chemical 4-hydroxy-6-[(3-sulfophenyl)amino]naphthalene-2-sulfonic acid in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of 4-hydroxy-6-[(3-sulfophenyl)amino]naphthalene-2-sulfonic acid in sediment is estimated to be 337.5 days (8100 hrs). Based on this half-life value, it indicates that 4-hydroxy-6-[(3-sulfophenyl)amino]naphthalene-2-sulfonic acid is persistent in sediment.
Biodegradation in Soil:
The half-life period of 4-hydroxy-6-[(3-sulfophenyl)amino]naphthalene-2-sulfonic acid (CAS No: 25251-42-7) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 80.5 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical 4-hydroxy-6-[(3-sulfophenyl)amino]naphthalene-2-sulfonic acid in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical 4-hydroxy-6-[(3-sulfophenyl)amino]naphthalene-2-sulfonic acid, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
Additional information
Biodegradation in water:
Predicted data for the target compound 4-hydroxy-6-[(3-sulfophenyl)amino]naphthalene-2-sulfonic acid (CAS No: 25251-42-7) and supporting weight of evidence studies for its read across substance were reviewed for the biodegradation end point which are summarized as below:
Biodegradability of test chemical 4-hydroxy-6-[(3-sulfophenyl)amino]naphthalene-2-sulfonic acid (CAS No: 25251-42-7) is predicted using OECD QSAR tool box v.3.3 using log Kow as primary descriptor. The test chemical 4-hydroxy-6-[(3-sulfophenyl)amino]naphthalene-2-sulfonic acid showed 4.48 % biodegradability by considering BOD as parameter and microorganisms as inoculum in 28 days. Since percent biodegradability is very low it is concluded that this test chemical is not readily biodegradable.
Another prediction done by using Estimation Programs Interface Suite (EPI suite, 2017) to estimate the biodegradation potential of the test chemical4-hydroxy-6-[(3-sulfophenyl)amino]naphthalene-2-sulfonic acid(CAS No: 25251-42-7) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical4-hydroxy-6-[(3-sulfophenyl)amino]naphthalene-2-sulfonic acidis not readily biodegradable.
In a supporting weight of evidence study from Authoritative database (J Check, 2017) of read across chemical 4-hydroxy-7-(phenylamino)naphthalene-2-sulfonic acid (CAS no.119-40-4) biodegradation experiment was carried out by taking sludge as inoculums. Biodegradation was analyzed by using three parameters that are O2 consumption, DOC removal and test material analysis by HPLC. The biodegradation test was conducted for 4 weeks (28 days).The read across chemical 4-hydroxy-7-(phenylamino)naphthalene-2-sulfonic acid showed 0 % degradation by O2 consumption parameter and test material analysis by HPLC parameter and 2 % degradation by DOC removal parameter in 28 days. So it is concluded that read across chemical 4-hydroxy-7-(phenylamino)naphthalene-2-sulfonic acid is not readily biodegradable.
In another supporting weight of evidence study from same source as mentioned above ( J Check, 2017) of read across chemical 6-Amino-4-hydroxy-2-naphthalenesulfonic Acid (CAS no. 90-51-7) biodegradation experiment was carried out by taking sludge as inoculums at concentration of 30 mg/L. Biodegradation was analyzed by using three parameters that are O2 consumption (BOD), TOC removal and test material analysis by UV vis . The biodegradation test was conducted for 2 weeks (14 days). The initial concentration of read across chemical used was 100 mg/L and test equipments used were of standard type. The test chemical 6-Amino-4-hydroxy-2-naphthalenesulfonic Acid showed 5.3 % degradation by O2 consumption (BOD) parameter, 0.4 % degradation by TOC removal parameter and less than 0.0% degradation by test material analysis by UV vis parameter in 14 days.So it is concluded that read across chemical 6-Amino-4-hydroxy-2-naphthalenesulfonic Acid is not readily biodegradable.
On the basis of above results for target chemical 4-hydroxy-6-[(3-sulfophenyl)amino]naphthalene-2-sulfonic acid (CAS No: 25251-42-7)from (EPI suite 2017 and OECD QSAR tool box v3.3 2017) and for its read across substances (from authoritative database) the target chemical 4-hydroxy-6-[(3-sulfophenyl)amino]naphthalene-2-sulfonic acid expected to be not readily biodegradable.
Biodegradation in water and sediments:
Estimation Programs Interface (EPI Suite, 2017) prediction model was run to predict the half-life in water and sediment for the test compound 4-hydroxy-6-[(3-sulfophenyl)amino]naphthalene-2-sulfonic acid (CAS No: 25251-42-7). If released in to the environment, 9.59 % of the chemical will partition into water according to the Mackay fugacity model level III and the half-life period of the chemical 4-hydroxy-6-[(3-sulfophenyl)amino]naphthalene-2-sulfonic acid in water is estimated to be 37.5 days (900 hrs). The half-life (37.5 days estimated by EPI suite) indicates that the chemical is not persistent in water and the exposure risk to aquatic animals is low whereas the half-life period of 4-hydroxy-6-[(3-sulfophenyl)amino]naphthalene-2-sulfonic acid in sediment is estimated to be 337.5 days (8100 hrs). Based on this half-life value, it indicates that 4-hydroxy-6-[(3-sulfophenyl)amino]naphthalene-2-sulfonic acid is persistent in sediment.
Biodegradation in Soil:
The half-life period of 4-hydroxy-6-[(3-sulfophenyl)amino]naphthalene-2-sulfonic acid (CAS No: 25251-42-7) in soil was estimated using Level III Fugacity Model by EPI Suite version 4.1 estimation database (EPI suite, 2017). If released into the environment, 80.5 % of the chemical will partition into soil according to the Mackay fugacity model level III. The half-life period of test chemical4-hydroxy-6-[(3-sulfophenyl)amino]naphthalene-2-sulfonic acid in soil is estimated to be 75 days (1800 hrs). Based on this half-life value of test chemical 4-hydroxy-6-[(3-sulfophenyl)amino]naphthalene-2-sulfonic acid, it is concluded that the chemical is not persistent in the soil environment and the exposure risk to soil dwelling animals is moderate to low.
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