3-(2-ethylhexyloxy)propylamine

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: basic information given

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1963

Report date:

1963

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

Principles of method if other than guideline:

according to BASF-internal standard

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-(2-ethylhexyloxy)propylamine

EC Number:

226-420-6

EC Name:

3-(2-ethylhexyloxy)propylamine

Cas Number:

5397-31-9

Molecular formula:

C11H25NO

IUPAC Name:

3-[(2-ethylhexyl)oxy]propan-1-amine

Test animals

Species:

rabbit

Strain:

Vienna White

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

other: untreated skin of the same animal

Amount / concentration applied:

ca. 1 mL

Duration of treatment / exposure:

1 min, 5 min, 15 min, 20 h

Observation period:

8 days

Number of animals:

2

Details on study design:

TEST SITE
- Area of exposure: 2.5 x 2.5 cm

REMOVAL OF TEST SUBSTANCE
- Washing (if done): 50% Lutrol

SCORING SYSTEM: Draize

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Remarks:

after 1 minute application

Basis:

mean

Time point:

other: 24 h

Score:

3

Max. score:

4

Reversibility:

not reversible

Remarks on result:

other: after 8 days necrosis

Results 2

Irritation parameter:

edema score

Remarks:

after 1 minute application

Basis:

mean

Time point:

other: 24 h

Score:

2

Max. score:

4

Reversibility:

not reversible

Results 3

Irritation parameter:

other: necrosis (5 minute application)

Basis:

mean

Time point:

other: 24 hours

Reversibility:

not reversible

Remarks on result:

other: after 24 hours full thickness necrosis

Irritant / corrosive response data:

Skin findings after 1 minute application: severe erythema and edema (skin hemorrhage) (reading after 24 hours).

Other effects:

Urine findings 24 hours after study end: albumin +, Hb spectroscopically +, sediment: hyalineand granular cylinder, after 6 days: nad.
Necropsy (8 days after study end): nothing abnormal detected

Any other information on results incl. tables

Results:

exposure duration	after 24 hours	after 8 days
1 minute	erythema score 3, edema score 3, bleedings	erythema score 2, necrosis
5 and 15 minutes	full thickness necrosis	full thickness necrosis
20 hours	full thickness necrosis	full thickness necrosis

Applicant's summary and conclusion

Interpretation of results:

corrosive

Remarks:

Migrated information