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EC number: 205-132-4 | CAS number: 134-20-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Determination of short-term toxicity of test chemical on Daphnia magna
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Common Name: Water Flea
Organism Age: < 24h - Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 18.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% C.I = 15.4mg/L - 21.3 mg/L
- Duration:
- 48 h
- Dose descriptor:
- NOELR
- Effect conc.:
- 5.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The EC50 and NOEL value of test chemical on Daphnia magna was determined to be 18.2mg/L and 5.5mg/L, respectively after 48h of exposure of test chemical.Since the test chemical is readily biodegradable the test chemical is considered to be nontoxic to Fish and cannot be classified according to CLP regulation.
- Executive summary:
An experimental study was conducted to determine the short term toxicity of test chemical to aquatic invertebrates. The test organism used in this study was Daphnia magna less than 24h old. The experiment was conducted in the static system using freshwater. After the exposure of test chemical for 48 h, the effect concentration EC50 and NOEL was determined to be 1 8.2 mg/L and 5.5mg/L, respectively. Since the test chemical is readily biodegradable the test chemical is considered to be nontoxic to Fish and cannot be classified according to CLP regulation.
Reference
Description of key information
An experimental study was conducted to determine the short term toxicity of test chemical to aquatic invertebrates. The test organism used in this study was Daphnia magna less than 24h old. The experiment was conducted in the static system using freshwater. After the exposure of test chemical for 48 h, the effect concentration EC50 and NOEL was determined to be 18.2 mg/L and 5.5 mg/L, respectively. Since the test chemical is readily biodegradable the test chemical is considered to be nontoxic to Fish and cannot be classified according to CLP regulation.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 18.5 mg/L
Additional information
Various experimental studies have been reviewed from different sources for target chemical and its structurally similar read across chemical to determine the short term toxicity of test chemical to aquatic invertebrates and their results are summarized below.
The first study was reviewed from authoritative database in this study an experimental study was conducted to determine the short term toxicity of test chemical to aquatic invertebrates. The test organism used in this study was Daphnia magna less than 24h old. The experiment was conducted in the static system using freshwater. After the exposure of test chemical for 48 h, the effect concentration EC50 and NOEL was determined to be 18.2 mg/L and 5.5mg/L, respectively. Since the test chemical is readily biodegradable the test chemical is considered to be nontoxic to aquatic invertebrates and cannot be classified according to CLP regulation.
Next study was reviewed from the study report in this an experiment was conducted to determine the short term toxicity of test chemical to aquatic invertebrates according to OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test). The test organism used in this study was Daphnia magna less than 24h old. The stock solution of test chemical was prepared by dissolving test chemical in acetone at concentration of 100 mg/l. Test solutions of required concentrations were prepared by mixing the stock solution of the test chemical in reconstituted water. The nominal concentration used in the study were 10, 20, 30, 45, 100 mg/l. The experiment was conducted in static system and test chemical was exposed to Daphnia magna. Effects on immobilisation were observed for 48 hours. With the test substance one positive control Potassium dichromate (K2Cr2O7) was also run simultaneously. After the exposure of chemical, effect concentration EC50 was calculated using nonlinear regression by the software Prism 4.0. The median effective concentration (EC50) for the test chemical, in Daphnia magna was determined to be 43.2 mg/L on the basis of mobility inhibition effects in a 48 hour study.
Last study was reviewed from secondary source in this study an experiment was conducted to determine the short term toxicity of test chemical to aquatic invertebrates. The test organism used in this study was Daphnia magna. The experiment was conducted in the static system using freshwater. After the exposure of test chemical for 24 h, the effect concentration EC50 was determined to be 50 mg/L. Since the test chemical is readily biodegradable the test chemical is considered to be nontoxic to aquatic invertebrates and cannot be classified according to CLP regulation.
By considering results of all the studies mentioned above the EC 50 value of test chemical was determined to be in range from 18.2 mg/L to 50 mg/L. Since the test chemical is readily biodegradable the test chemical is considered to be nontoxic to aquatic invertebrates and cannot be classified according to CLP regulation.
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