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EC number: 207-668-4 | CAS number: 488-10-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Report contains tabulated results only. The study was conducted prior to introduction of GLP and current test guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The study was conducted prior to development of current guidelines. Reporting of the methodology is poor; the study does not appear to conform to current guidelines but generally follows the method of Draize - irritation was assessed following a single application, and following 7 daily applications.
- GLP compliance:
- no
- Remarks:
- Conducted prior to development of GLP
Test material
- Reference substance name:
- 3-methyl-2-pent-2-enylcyclopent-2-enone
- EC Number:
- 207-668-4
- EC Name:
- 3-methyl-2-pent-2-enylcyclopent-2-enone
- Cas Number:
- 488-10-8
- Molecular formula:
- C11H16O
- IUPAC Name:
- 3-methyl-2-pent-2-enylcyclopent-2-enone
- Reference substance name:
- (E)-3-methyl-2-(pent-2-enyl)cyclopent-2-en-1-one
- EC Number:
- 228-410-7
- EC Name:
- (E)-3-methyl-2-(pent-2-enyl)cyclopent-2-en-1-one
- Cas Number:
- 6261-18-3
- Molecular formula:
- C11H16O
- IUPAC Name:
- 3-methyl-2-pent-2-en-1-ylcyclopent-2-en-1-one
- Test material form:
- liquid
Constituent 1
impurity 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- Rabbits were used, no further information is provided
Test system
- Vehicle:
- other: Neantime; diethyl benzene-1,2-dicarboxylate
- Controls:
- yes, concurrent vehicle
- Amount / concentration applied:
- Test concentrations for the single application were 100%, 30%, 10%, 3% and 1%
Test concentrations for the repeat applications were 10%, 3% and 1% (based on results obtained in the single application study).
The vehicle used was neantime. - Duration of treatment / exposure:
- The irritation was assessed following a single application of the test substance initially and then proceeded to repeated application for 7 consecutive days.
- Observation period (in vivo):
- Observations were made for 7 days after the last application
- Number of animals or in vitro replicates:
- No information provided
- Details on study design:
- Irritation was scored according to the following system:
- = no reaction
(+) = slight redness
+ = moderate redness and secretion
++ = strong redness and strong secretion
+++ = strong redness and strong secretion and oedema
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Remarks:
- Based on the results provided on the irritation test on the rabbit eye, it is concluded that this substance does cause eye irritation at 3%.
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 48 h
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Remarks:
- Based on the results provided on the irritation test on the rabbit eye, it is concluded that this substance does cause eye irritation at 100%.
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Reversibility:
- not specified
- Remarks on result:
- positive indication of irritation
- Remarks:
- Based on the results provided on the irritation test on the rabbit eye, it is concluded that this substance does cause eye irritation at 100%.
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Remarks:
- not specified
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Remarks:
- not specified
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Remarks:
- not specified
- Irritant / corrosive response data:
- Single application: no reactions were observed following treatment with the 1% concentration. Treatment with 3% caused slight redness 1 day after application that had completely resolved by day 2. Treatment with 30% caused moderate redness and secretion 1 day after application, which reduced to slight redness 2 days after application. Signs of irritation had resolved by Day 3. Treatment with the undiluted test substance caused strong redness, strong secretion and oedema 1 day after application; signs of irritation ameliorated from then on and eyes were completely free of irritation by Day 6.
Repeat applications: no reactions were observed following 7 days repeat exposure to the 1% concentration. 7 days repeat treatment with the 3% and 10% concentrations resulted in slight redness at each observation, which persisted to study termination on Day 7.
The vehicle (neantime) was reported to have a highest non-irritant concentration of 10% following single application, and 100% following repeat application. - Other effects:
- No other effects reported.
Any other information on results incl. tables
A: Single application:
Substance |
Lowest irritant concentration |
Highest non-irritant concentration |
Giv 1-0985 Ro 6-8198 |
3% |
1% |
Solvent |
- |
10% |
Duration of the lesions:
Substance |
Concentration % |
Day 1 |
Day 2 |
Day 3 |
Day 4 |
Day 5 |
Day 6 |
Day 7 |
Giv 1-0985 Ro 6-8198 |
100 |
+++ |
++ |
+ |
(+) |
(+) |
- |
- |
30 |
+ |
(+) |
- |
- |
- |
- |
- |
|
10 |
(+) |
- |
- |
- |
- |
- |
- |
|
3 |
(+) |
- |
- |
- |
- |
- |
- |
|
1 |
- |
- |
- |
- |
- |
- |
- |
|
Solvent |
100 |
- |
- |
- |
- |
- |
- |
- |
Evaluation:
- = No reaction
(+) = Slight redness
+ = Slight redness and secretion
++ = Moderate redness and strong secretion
+++ = Strong redness and strong secretion and oedema
B: Repeated application on 7 consecutive days-Score after last application:
Substance |
Lowest irritant concentration |
Highest non-irritant concentration |
Giv 1-0985 Ro 6-8198 |
3% |
1% |
Solvent |
- |
10% |
Substance |
Concentration % |
Day 1 |
Day 2 |
Day 3 |
Day 4 |
Day 5 |
Day 6 |
Day 7 |
Giv 1-0985 Ro 6-8198 |
100 |
Not done |
|
|
|
|
|
|
30 |
Not done |
|
|
|
|
|
|
|
10 |
(+) |
(+) |
(+) |
(+) |
(+) |
(+) |
(+) |
|
3 |
(+) |
(+) |
(+) |
(+) |
(+) |
(+) |
(+) |
|
1 |
- |
- |
- |
- |
- |
- |
- |
|
Solvent |
100 |
- |
- |
- |
- |
- |
- |
- |
Evaluation:
- = No reaction
(+) = Slight redness
+ = Slight redness and secretion
++ = Moderate redness and strong secretion
+++ = Strong redness and strong secretion and oedema
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information at 3% concentration Criteria used for interpretation of results: EU
- Conclusions:
- Based on the results provided on the irritation test on the rabbit eye, it is concluded that this substance does cause eye irritation at 3%.
- Executive summary:
The eye irritation potential of Jasmone was evaluated in rabbits. A single application was made to the rabbit eye at concentrations of 100%, 30%, 10%, 3% and 1% (in neantime). Signs of irritation were recorded daily for 7 days after application. In addition, concentrations of 10%, 3% and 1% were applied daily for 7 days and signs of irritation recorded daily for 7 days after the last application. A single application of 3, 10 or 30% test substance caused slight redness (erythema) which resolved by Day 2. No irritant reactions were observed following treatment with 1%. A single application of 100% test substance caused strong redness (erythema), secretion and oedema; symptoms reduced over the following days and eyes were free from irritation by Day 6. Repeated application with 1% test substance caused no adverse effects. Slight redness (erythema) was observed following 7 -days repeat application with 3% and 10% test substance; effects persisted to study termination (7 days after the last application). The vehicle (neantime) was reported to have a highest non-irritant concentration of 10% following single application, and 100% following repeat application.
It was concluded that the highest non-irritating concentration of the test substance was 1%, and the lowest irritant concentration was 3%.
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