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EC number: 203-687-7 | CAS number: 109-61-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets scientific standards with acceptable restrictions (limited documentation, e.g. no details about test substance or applied amount of test substance)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
Materials and methods
- Principles of method if other than guideline:
- Skin irritation was tested using an internal standard method (BASF test). White Vienna rabbits were used. Usually, 2 animals were treated for 1, 5 and 15 minutes and 2 other animals for 20 hours using occlusive conditions. An application site of 2.5 X 2.5 cm was covered with the liquid or powdered and moistened test substance.
- GLP compliance:
- no
Test material
- Reference substance name:
- Propyl chloroformate
- EC Number:
- 203-687-7
- EC Name:
- Propyl chloroformate
- Cas Number:
- 109-61-5
- Molecular formula:
- C4H7ClO2
- IUPAC Name:
- propyl carbonochloridate
- Details on test material:
- - Name of test material (as cited in study report): n-Propyl-chlorkohlensaeureester
- Physical state: liquid
- Purity: approx. 95%
- Expiration date of the lot/batch: not reported
- Stability under test conditions: not reported
- Storage condition of test material: not reported
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Breeder
- Weight at study initiation: 2.8 - 2.9 kg
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): approx. 1 ml - Duration of treatment / exposure:
- Experiment 1: 20 h
Experiment 2: 1, 5, or 15 minutes - Observation period:
- Experiment 1: up to 8 days
Experiment 2: up to 8 days
(Killing on d 9) - Number of animals:
- Experiment 1: 2
Experiment 2: 2 - Details on study design:
- TEST SITE
- Area of exposure: An application site of 2.5 X 2.5 cm was covered with the liquid (37°C; presumably 1 ml)
REMOVAL OF TEST SUBSTANCE
- Washing (if done):
Experiment 1: washing was done in the 1 min, 5 min and 15 min test directly after exposure. Lutrol conc. and 50% (mild detergent) was used.
Experiment 2: No washing was done after the 20 h treatment.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- other: mean (20 h exposure)
- Time point:
- 24 h
- Score:
- 2.5
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 8 d
- Remarks on result:
- other: red, partially hard necrosis observed in both animals
- Irritation parameter:
- edema score
- Basis:
- other: mean (20 h exposure)
- Time point:
- 24 h
- Score:
- 1.75
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 8 d
- Remarks on result:
- other: slight redness observed in 1/2 animals
- Irritation parameter:
- erythema score
- Basis:
- other: mean (15 min exposure)
- Time point:
- 24 h
- Score:
- 2.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 d
- Remarks on result:
- other: redish, hard necrosis observed in both animals
- Irritation parameter:
- edema score
- Basis:
- other: mean (15 min exposure)
- Time point:
- 24/48 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Remarks on result:
- other: slight edema observed in both animals
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- ( 20 h exposure)
- Time point:
- 48 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 8 d
- Remarks on result:
- other: red hart necrosis with cross wrinkle
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- (20 h exposure)
- Time point:
- 48 h
- Score:
- 2.5
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 8 d
- Remarks on result:
- other: red hart necrosis with cross wrinkle
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- (15 min exposure)
- Time point:
- 48 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 d
- Remarks on result:
- other: bloody, yellow-brown areas on the whole back
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- (15 min exposure)
- Time point:
- 48 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 8 d
- Remarks on result:
- other: bloody, yellow-brown areas on the whole back
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- (20 h exposure)
- Time point:
- 72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- (20 h exposure)
- Time point:
- 72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- (15 min exposure)
- Time point:
- 72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- (15 min exposure)
- Time point:
- 72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
Any other information on results incl. tables
Since irritation data are recommended for a 4 h skin exposition, results of the available 20 h and the 15 min exposition will serve as approximation.
Descriptive scores of the raw data have been converted to Draize numerical scores. If necroses were reported, erythema scores were given for the surrounding area.
Exposition: |
20 h |
|||
Animal |
Reading |
Erythema |
Edema |
Comment |
1 |
24 h |
3 |
0 |
anemic necrosis, bloody surrounding area |
2 |
24 h |
2 |
3 |
overlapping; surrounding white |
1 |
48 h |
2 |
2 |
red hart necrosis with cross wrinkle |
2 |
48 h |
2 |
3 |
red pale necrosis |
1 |
5 d |
2 |
2 |
red hart necrosis with cross wrinkle |
2 |
5 d |
2 |
3 |
red pale necrosis |
1 |
7 d |
2 |
2 |
red hart necrosis with cross wrinkle |
2 |
7 d |
0 |
0 |
necrosis border starts to peel off |
1 |
8 d |
2 |
2 |
red hart necrosis with cross wrinkle |
2 |
8 d |
0 |
0 |
necrosis border starts to peel off |
mean |
24 - 48 h |
2.25 |
2.00 |
|
Exposition: |
15 min |
|||
Animal |
Reading |
Erythema |
Edema |
Comment |
3 |
24 h |
4 |
2 |
skin bloody |
4 |
24 h |
1 |
0 |
overlaping |
3 |
48 h |
4 |
2 |
bloody, yellow-brown areas on the whole back |
4 |
48 h |
2 |
2 |
yellow-brown areas on the whole back |
3 |
5 d |
4 |
3 |
red-yellow, hard necrosis, surrounding area partially anemic |
4 |
5 d |
3 |
3 |
pergamentous, redish, hard necrosis |
3 |
7 d |
4 |
3 |
red-yellow, hard necrosis, surrounding area partially anemic |
4 |
7 d |
3 |
3 |
pergamentous, redish, hard necrosis |
3 |
8 d |
4 |
3 |
red-yellow, hard necrosis, surrounding area partially anemic |
4 |
8 d |
3 |
3 |
pergamentous, redish, hard necrosis |
mean |
24 - 48 h |
2.75 |
1.50 |
|
Applicant's summary and conclusion
- Executive summary:
This study meets scientific standards with acceptable restrictions (limited documentation, e.g. no details about test substance). Skin irritation was tested using an internal standard method (BASF test). White Vienna rabbits were used. Usually, 2 animals were treated for 1, 5 and 15 minutes and 2 other animals for 20 hours using occlusive conditions. An application site of 2.5 x 2.5 cm was covered with the test substance
The test substance induced 8 days persistent erythema and necrosis after 15 min and 20 h exposure. The test substance has to be regarded as corrosive.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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