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EC number: 940-272-6 | CAS number: 2097734-13-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Two acute toxicity tests were conducted, an oral and a dermal study. For both exposure routes, the acute oral median lethal dose (LD50) of the test material in rats was estimated to be greater than 2000 mg/kg bodyweight.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05.11.2014 to 01.07.2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: Rat (Rattus norvegicus) / CD / Crl: CD(SD)
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Species / Strain / Stock: Rat (Rattus norvegicus) / CD / Crl: CD(SD)
Supplier: Charles River Laboratories, Research Models and Services, Germany GmbH, Sandhofer Weg 7, 97633 Sulzfeld, Germany
Selection of species: International recommendations; EC, OECD and OCSPP (OPPTS) guidelines
Sex: Female
Number of animals: 6 female animals
Group: 1 dose level group of 6 female animals - Limit test -
Body weight (at start of 1st administration): 170 - 200 g
Age (at start of administration) Approx: 8 weeks
Identification of animals: By coloured marks and cage label
Duration of experiment: At least 5 adaptation days 1 test day 2 recovery weeks - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Administration volume: 1.96 mL/kg b.w.
- Doses:
- Dose level: 2000 mg/kg b.w. (limit test)
- No. of animals per sex per dose:
- 6 female animals
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations were performed before and immediately, 5, 15, 30 and 60 min, as well as 3, 6 and 24 hours after administration. Individual body weights were recorded before administration of the test item and thereafter in weekly intervals up to the end of the study.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross pathology - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- none
- Clinical signs:
- other: none
- Gross pathology:
- none
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this experiment Di-(iso)-pentyl-terephthalate (DPT) was examined for acute toxicity after a single oral administration to rats (limit test).
Under the present test conditions, a single oral administration of 2000 mg Di-(iso)-pentyl-terephthalate (DPT)/kg b.w. did not reveal any clinical signs of toxicity.
All animals gained the expected body weight at the end of the study period.
No pathological changes were observed at necropsy.
The LD50 value was ranked exceeding 2000 mg/kg b.w..
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2015-03-10 to 2015-06-12
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- adopted Feb 24, 1987
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- other: CD/Crl:CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories (Sulzfeld, Germany)
- Age at study initiation: Males approx. 8 weeks, Females approx. 10 weeks
- Weight at study initiation: Males: 211-250 g, Females: 206-224 g
- Housing: granulated textured wood, MAKROLON cages during observation period
- Diet (e.g. ad libitum): discontinued approx. 16 h before administration
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3
- Humidity (%): 55 +/- 15
- Photoperiod (hrs dark / hrs light): 12 h each - Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back between the fore and hind extremities (5 cm x 6 cm)
- % coverage: 10 % of body surface
- Type of wrap if used: in contact with the skin with 8 layers of gauze
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1.96 mL/kg b.w. - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg b.w.
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Observations: before and immediately, 5, 15, 30 and 60 min, 3, 6 and 24 h after administration. All animals were observed for a period of 14 days.
Body weights: before administration and after in weekly intervals up to the end
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, skin reactions, mortality, necropsy findings - Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Effect level above the highest dose
- Mortality:
- No death was recorded.
- Clinical signs:
- other: Not observed
- Gross pathology:
- No signs of abnormalities were noted at necropsy.
- Other findings:
- No skin reactions were observed at the application site.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute median lethal dermal dose (LD50) to rats of Di-(iso)-pentyl terephthalate (DPT) was demonstrated to be greater than 2000 mg/kg bodyweight (limit test). No deaths, clinical signs and macroscopic necropsy findings were observed. No classification is needed.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
Additional information
Acute oral toxicity study:
In this experiment Di-(iso)-pentyl-terephthalate (DPT) was examined for acute toxicity after a single oral administration to rats (limit test). The method was designed to meet the requirements of the OECD guideline 423, EC method B.1 tris - ATC method - and OCSPP (OPPTS) guideline 870.1100.
Under the present test conditions, a single oral administration of 2000 mg Di-(iso)-pentyl-terephthalate (DPT)/kg b.w. did not reveal any clinical signs of toxicity.
All animals gained the expected body weight at the end of the study period.
No pathological changes were observed at necropsy.
The LD50value was ranked exceeding 2000 mg/kg b.w. by oral administration.
Acute dermal toxicity study:
In this experiment Di-(iso)-pentyl terephthalate (DPT) was examined for acute toxicity after a single dermal application to rats. One dose level of 2000 mg/kg b.w. was employed (limit test). The method was designed to meet the requirements of the OECD guideline 402, EC method B.3 and OCSPP (OPPTS) 870.1200.
Under the present test conditions, a single dermal administration of 2000 mg
Di-(iso)-pentyl terephthalate (DPT)/kg b.w. did not reveal any signs of toxicity. No death was recorded within the test period (one dosing day and 14 recovery days).
All animals gained the expected weight throughout the whole study period.
No skin reactions were observed at the application site.
No signs of abnormalities were noted at necropsy.
The LD50value was ranked exceeding 2000 mg/kg b.w. by dermal administration.
Justification for classification or non-classification
Based on the available studies, the test substance is not classified for acute toxicity according to EC Regulation No. 1272/2008.
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