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EC number: 200-665-9 | CAS number: 67-71-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- genetic toxicity in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Data is from peer-reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Evaluation of Genotoxicity on Plant-Derived Dietary Sulfur
- Author:
- LEE, YOON-IK
- Year:
- 2 006
- Bibliographic source:
- J. Microbial. Biotechnol.
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The in vivo micronucleus test was carried out in mouse bone marrow, to find out genetic effect of dimethyl sulphone (Methylsulfonylmethane).
- GLP compliance:
- no
- Type of assay:
- other: micronucleus assay
Test material
- Reference substance name:
- Dimethyl sulphone
- EC Number:
- 200-665-9
- EC Name:
- Dimethyl sulphone
- Cas Number:
- 67-71-0
- Molecular formula:
- C2H6O2S
- IUPAC Name:
- dimethyl sulphone
- Details on test material:
- Details on test material
- Name of test material (as cited in study report): Methylsulfonylmethane
- Molecular formula (if other than submission substance): C2-H6-O2-S
- Molecular weight (if other than submission substance): 94.1334 g/mol
- Substance type: Organic
- Physical state: Solid
Purity: No data available
- Impurities (identity and concentrations): No data available
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- - Vehicle(s)/solvent(s) used: Carboxymethylcellulose
- Justification for choice of solvent/vehicle: No data available
- Concentration of test material in vehicle: No data available
- Amount of vehicle (if gavage or dermal): 0.5% w/v (vehicle control group)
- Type and concentration of dispersant aid (if powder): No data available
- Lot/batch no. (if required): No data available
- Purity: No data available - Details on exposure:
- No data available
- Duration of treatment / exposure:
- 48 hr
- Frequency of treatment:
- Once
- Post exposure period:
- No data available
Doses / concentrationsopen allclose all
- Dose / conc.:
- 1 250 other: mg/kg
- Dose / conc.:
- 2 500 other: mg/kg
- Dose / conc.:
- 5 000 other: mg/kg
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Positive control(s):
- Positive controls: mitomycin C
- Justification for choice of positive control(s): No data available
- Route of administration: intra peritoneal (i.p)
- Doses / concentrations: 4 mg/kg
Examinations
- Tissues and cell types examined:
- bone marrow
- Details of tissue and slide preparation:
- No data available
- Evaluation criteria:
- No data available
- Statistics:
- No data available
Results and discussion
Test results
- Sex:
- not specified
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- valid
- Negative controls validity:
- not specified
- Positive controls validity:
- valid
- Remarks on result:
- other: non mutagenic
- Additional information on results:
- RESULTS OF RANGE-FINDING STUDY
- Dose range: No data available
- Solubility: No data available
- Clinical signs of toxicity in test animals: No data available
- Evidence of cytotoxicity in tissue analyzed: No data available
- Rationale for exposure: No data available
- Harvest times: No data available
- High dose with and without activation: No data available
- Other:
RESULTS OF DEFINITIVE STUDY
- Types of structural aberrations for significant dose levels (for Cytogenetic or SCE assay): No data available
- Induction of micronuclei (for Micronucleus assay): No data available
- Ratio of PCE/NCE (for Micronucleus assay): No data available
- Appropriateness of dose levels and route: No data available
- Statistical evaluation: No data available
Applicant's summary and conclusion
- Conclusions:
- The micronucleus assay results confirmed that test substance at doses up to 5000 mg/kg did not exhibit any genotoxicity in mouse bone marrow.
- Executive summary:
The in vivo micronucleus test was carried out in mouse bone marrow, to find out genetic effect of test substance . Methylsulfonylmethane was administered to group of mice using an oral gavage at doses of 1250, 2500, 5000mg/kg. The vehicle control groups received carboxymethyl cellulose at an equivalent oral volume of 0.5% w/v, whereas the positive control group received an i.p. dose of mitomycin C at 4mg/kg. No significant difference in body weight was noted between test substance treated mice and the solvent control. The number of micronucleated polychromatic erythrocytes, where the frequency in the solvent control was 0.4±0.5, the frequency in the positive control was 12.2±1.2, which was significantly higher and the frequency after test substance treatment with 1250, 2500, 5000mg/kg was 0.1±0.5, 0.5±0.5 and 0.4±0.5 respectively. Therefore, the test substance treatment did not cause any change in the frequency of micronucleated polychromatic erythrocytes when compared with the solvent control. Consequently, the micronucleus assay results confirmed that test substance at doses up to 5000 mg/kg did not exhibit any genotoxicity in mouse bone marrow.
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