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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 942-732-1 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- genetic toxicity in vitro
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- other: expert assessment
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: An assessment was conducted based on an examination of the composition of the substance and the potential of its constituents to induce gene mutation in bacteria.
Data source
Reference
- Reference Type:
- other: expert assessment
- Title:
- Unnamed
- Year:
- 2 016
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- An assessment was conducted based on an examination of the composition of the substance and the potential of its constituents to induce gene mutation in bacteria.
- GLP compliance:
- no
- Type of assay:
- other: An assessment was conducted based on an examination of the composition of the substance and the potential of its constituents to induce gene mutation in bacteria.
Test material
- Reference substance name:
- Reaction mass of 2-aminoethanol and 6-[(p-tosyl)amino]hexanoic acid, compound with 2-aminoethanol (1:1)
- EC Number:
- 942-732-1
- Molecular formula:
- C13H19NO4S.C2H7NO/C2H7NO/H2O
- IUPAC Name:
- Reaction mass of 2-aminoethanol and 6-[(p-tosyl)amino]hexanoic acid, compound with 2-aminoethanol (1:1)
- Reference substance name:
- Reaction mass of 2-aminoethanol and 6-[(p-tosyl)amino]hexanoic acid, compound with 2-aminoethanol (1:1)
- IUPAC Name:
- Reaction mass of 2-aminoethanol and 6-[(p-tosyl)amino]hexanoic acid, compound with 2-aminoethanol (1:1)
- Test material form:
- other: liquid
- Details on test material:
- Name of test material: Reaction mass of 2-aminoethanol and 6-[(p-tosyl)amino]hexanoic acid, compound with 2-aminoethanol (1:1)Physical state: pale yellow liquidSubstance type: multi-constituent substance
Constituent 1
Constituent 2
Results and discussion
Test results
- Key result
- Genotoxicity:
- negative
- Remarks on result:
- other: assessment conducted based on an examination of the composition of the substance and the potential of its constituents to induce gene mutation in bacteria
Any other information on results incl. tables
An assessment was conducted based on an examination of the composition of the substance and the potential of its constituents to induce gene mutation in bacteria.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):negativeBased on an examination of the capacity of its constituents to induce gene mutation in bacteria, it is concluded that the registered substance is not expected to induce gene mutation in mammalian cells. The registered substance does not meet the criteria for classification according to Regulation (EC) No.1272/2008 on the Classification, Labelling and Packaging of Substances and Mixtures.
- Executive summary:
The potential of reaction mass of 2-aminoethanol and 6-[[(4-methylphenyl)sulphonyl]amino]hexanoic acid, compound with 2-aminoethanol (1:1) to induce gene mutation in bacteria is expected to be driven by the capacity of its constituents – 6-[[(4-methylphenyl)sulphonyl]amino]hexanoic acid, 2-aminoethanol, and water – to induce gene mutation in bacteria.
A GLP study has been performed on 6-[[(4-methylphenyl)sulphonyl]amino]hexanoic acid according to OECD Guideline 471 and concluded that the substance is negative for gene mutation in bacteria with and without metabolic activation.
The QSAR predictions performed on 2-aminoethanol demonstrated that the substance is not expected to induce gene mutation in bacteria. This conclusion supports a non-GLP study conducted in 1984 by Mortelmans et al. using a method equivalent to OECD Guideline 471, which found 2-aminoethanol to be negative for gene mutation in bacteria with and without metabolic activation.
Based on the activity of its constituents, it is concluded that reaction mass of 2-aminoethanol and 6-[[(4-methylphenyl)sulphonyl]amino]hexanoic acid, compound with 2-aminoethanol (1:1) is not expected to induce gene mutation in bacteria. No further testing is considered as required.
Maron D (1983) Revised Methods for the Salmonella Mutagenicity Test. Mutation Res., 113, 173-215.
Mortelmans K (1986) Salmonella Mutagenicity Tests: II. Results From the Testing of 270 Chemicals. Journal of the Environmental Society 8 (Suppl. S7): 56–119
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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