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Diss Factsheets
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EC number: 400-820-2 | CAS number: 84268-33-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically accepted calculation method
Data source
Reference
- Reference Type:
- other: estimation software
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSAR R.6, May 2008
- Deviations:
- not applicable
- Principles of method if other than guideline:
- The computer program ECOSAR (v1.00) by US-EPA is used for this estimation. ECOSAR is a scientifically accepted calculation method for organic chemicals; it estimates the toxicity of chemicals discharged to water and predicts beside the acute (short-term) toxicity also the chronic (long-term or delayed) toxicity of a chemical.
- GLP compliance:
- no
- Remarks:
- not applicable
Test material
- Reference substance name:
- -
- EC Number:
- 400-820-2
- EC Name:
- -
- Cas Number:
- 84268-33-7
- Molecular formula:
- C20H23N3O3
- IUPAC Name:
- Methyl 3-[3-(2H-benzotriazol-2-yl)-4-hydroxy-5-(2-methyl-2-propanyl)phenyl]propanoate
- Test material form:
- not specified
- Details on test material:
- SMILES notation: COC(=O)CCC1=CC(=C(O)C(=C1)N1N=C2C=CC=CC2=N1)C(C)(C)C
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not required
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- other: Green algae; detailed species not reported
Study design
- Test type:
- other: calculation
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Reference substance (positive control):
- not required
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.051 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- not specified
- Basis for effect:
- growth rate
- Remarks on result:
- other: no algal cell growth inhibition up to its limit of solubility in water
- Details on results:
- Due to its very low water solubility the substance may not be soluble enough to measure this predicted effect. Further, as the logKow is greater than 5 and the EC50 exceeds the water solubility by factor 10 or more, no effects at saturation are predicted.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- EC50 for green algae (96h) = 1.051 mg/L, but the substance may not be soluble enough to measure this predicted effect.
- Executive summary:
The short-term toxicity value (acute) of the substance of interest for green algae was determined by calculation. This calculation was performed by the computer program form US-EPA (EPIWIN software ECOSAR v1.00); result: EC50(96 h) for green algae = 1.051 mg/L.
Nevertheless, the water solubility (IUCLID section 4.8) and the logKow (IUCLID section 4.7) of a chemical should be compared with the predicted toxicity value derived for a chemical. If the logKow (5.1) is greater than 5 and the LC50 exceeds the measured or predicted maximum water solubility (<0.05 mg/L) by factor 10 or even more then an effect is not expected to occur in a saturated solution.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.