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Diss Factsheets
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EC number: 203-751-4 | CAS number: 110-27-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
8. PBT AND VPVB ASSESSMENT
8.1. Assessment of PBT/vPvB Properties
8.1.1. Summary and overall conclusions on PBT or vPvB properties
The results reported in Chapter 4.1 Degradation indicate that the substance is neither
persistent (not P) nor very persistent (not vP) in the environment.
Furthermore the results reported in Chapter 4.3 Bioaccumulation demonstrate that the
substance has a low potential to be bioaccumulative (not B) and is not very bioaccumulative
(not vB). Based on the results obtained from the aquatic toxicity studies documented in
Chapter 7.1 (Aquatic compartment including sediment) and the data on mammalian toxicity
studies (Chapter 5. Human Health Hazard Assessment), the substance is considered not toxic
(not T).
8.1.2. PBT/vPvB criteria and justification
Data for the definitive conclusion on the PBT or vPvB properties of the substance are not
available. Thus, the screening criteria given in the ‘Guidance on information requirements and
chemical safety assessment, chapter R.11: PBT assessment’ (ECHA, 2008) are used as
surrogate information to decide whether the substance may potentially fulfil the PBT or vPvB
criteria.
Persistence Assessment
The screening criterion for persistence is the potential of a substance for ready
biodegradation. As the substance Isopropyl myristate is readily biodegradable, the substance
is considered to be not persistent and does not meet the “P” criterion.
Bioaccumulation Assessment
The screening criterion for bioaccumulative substances, which has to be classified as “B” or
“vB”, is a log Kow > 4.5. The log Kow value (calculated) of the test substance is 7.71
(Chapter 1.3). As a result, the substance Isopropyl myristate is predicted to bioaccumulate on
the basis of its physico-chemical properties. However, as the substance is readily
biodegradable, no chronic exposure of aquatic organisms is expected. Should the substance be
taken up by fish, the group of linear aliphatic fatty acid esters has been shown to be rapidly
metabolised and excreted via the enzyme carboxylesterase. A QSAR calculation reveals a
bioaccumulation potential with 2765 L/kg as regression based estimate, however a low
bioaccumulation potential with the more realistic Arnot-Gobas method including
biotransformation with a resulting BCF value of 122.1 L/kg (upper trophic). Therefore, in
accordance with the ECHA Guidance Document R.11, the substance has presumably a low
potential to be bioaccumulative (BCF < 2000 L/kg) and is not very bioaccumulative (BCF <
5000 L/kg).
Toxicity Assessment
The screening criterion for toxicity is based on short-term aquatic toxicity studies. Aquatic
organisms (algae, daphnia, and fish) did not show any toxicity up to the limit of the water
solubility (< 0.05 mg/L). Hence, the substance will not be classified as “T” substance.
In addition, the substance is not classified as carcinogenic, mutagenic or toxic for
reproduction nor is there any evidence of chronic toxicity according to Directive 67/548/EEC
and Regulation (EC) No 1272/2008. Therefore, the substance does not meet the “T” criterion.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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