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EC number: 292-602-7 | CAS number: 90640-80-5 A complex combination of polycyclic aromatic hydrocarbons obtained from coal tar having an approximate distillation range of 300°C to 400°C (572°F to 752°F). Composed primarily of phenanthrene, anthracene and carbazole
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Creosote
- EC Number:
- 232-287-5
- EC Name:
- Creosote
- Cas Number:
- 8001-58-9
- Molecular formula:
- not applicable
- IUPAC Name:
- Creosote
- Test material form:
- liquid
- Details on test material:
- - Substance type: organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Creosote; North American P1/P13 Creosote; North American Creosote Composite Test Material P1/P13
- Composition of test material, percentage of components: see under Test material information
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Remarks:
- Crl:CD® BR VAF/Plus®
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Portage, Michigan, USA
- Age at study initiation: 53 – 75 days
- Weight at study initiation: males: 234 – 283 g, females: 192 – 216 g
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Mass median aerodynamic diameter (MMAD):
- >= 1.3 - <= 3.4 µm
- Geometric standard deviation (GSD):
- >= 1.65 - <= 1.98
- Details on inhalation exposure:
- MMAD ± GSD [µm]:
5000 mg/m³: 3.4 ± 1.89 (2.5 % of particles ≤ 1 µm diameter)
600 mg/m³: 1.3 ± 1.64 (29 % of particles ≤ 1 µm diameter) - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- GC-FID after sampling (9 key aromatics quantified (approx. 50 % of creosote), then result extrapolated to total creosote by using a factor of 1.64)
- Duration of exposure:
- 4 h
- Concentrations:
- 600, 5000 mg/m³ (analytical)
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 5 000 mg/m³ air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: concentration in air was determined gravimetrically
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5 000 mg/m³ air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: highest concentration tested
- Mortality:
- No deaths occurred at maximum dose.
- Clinical signs:
- other: 5000 mg/m³: Directly after exposure, 9/10 animals with reduced activity. Three males and one female showed increased salivation. During the 14-day post-exposure period, five males and four females exhibited decreased activity. 600
- Body weight:
- 5000 and 600 mg/m³: bw gain depressed, persisted for 14 days post exposure.
- Gross pathology:
- No significant macroscopic abnormalities were found at necropsy.
Any other information on results incl. tables
Table A6_1-1. Table for Acute Toxicity (inhalation) |
||||||
Dose[mg/m3air] |
Toxicological results* |
Duration of clinical signs |
Time of death |
Mortality (%) |
Particles£5mm (%) |
|
males |
||||||
600 |
0/2/5 |
4h – 14d |
- |
- |
99 |
|
5000 |
0/5/5 |
4h – 14d |
- |
- |
53 |
|
LC50value > 5000 mg/m3air (aerosol) |
|
|||||
females |
||||||
600 |
0/0/5 |
4h – 14d |
- |
- |
99 |
|
5000 |
0/4/5 |
4h – 14d |
- |
- |
53 |
|
LC50value > 5000 mg/m3air (aerosol) |
|
*number of dead animals / number of animals with clinical signs of toxicity / total number of animals
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- as well as EU criteria according to CLP regulation
- Conclusions:
- Based on the results of this study, the four-hour inhalation LC50 for Creosote P1/P13 was greater than 5000 mg/m³.
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