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EC number: 203-294-0 | CAS number: 105-39-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 21.02.1979 to 29.05.1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No data on guidelines but the test method is similar to OECD 401.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- The examination of acute oral toxicity was performed on female Wistar rats with an observation period of 14 days
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Ethyl chloroacetate
- EC Number:
- 203-294-0
- EC Name:
- Ethyl chloroacetate
- Cas Number:
- 105-39-5
- Molecular formula:
- C4H7ClO2
- IUPAC Name:
- ethyl 2-chloroacetate
- Details on test material:
- - Name of test material (as cited in study report): Monoehloressigsaureathylester
- Physical state: colorless liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 160-182 g (172 g ± 6,08 g; n=40)
- Fasting period before study: 16 hours
- Housing: Housing of the animals was carried o ut in groups in plastic cages with wood shavings.
- Diet (e.g. ad libitum): No feeding during 2 first hours post administration. During the test period of 14 days after administration, animals were feed ad libitum. Maintenance diet: Altromin 1324 (Altromin GmbH, Lage/Lipe).
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS: No data
IN-LIFE DATES: From: 21.02.1979 To: 14.03.1979
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 5g/100 mL - Doses:
- 80, 125, 200 and 315 mg/kg bodyweight
- No. of animals per sex per dose:
- 10 female rats per dose (The study was performed on female rats because preliminary experiments demonstrated that they were more sensitive to toxicity)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Weekly
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs of poisoning and body weight. Fatally poisoned animals were dissected and the macroscopic autopsy findings were recorded. - Statistics:
- The LD 50 was calculated using Probit (method according to Linder and Weber). The confidence limits were calculated according to CAVALLI-SFORZA(programmed by Department of Applied Mathematics of Hoechst Aktiengesellschaft).
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 180 mg/kg bw
- 95% CL:
- 150.57 - 215.27
- Mortality:
- Mortality rate and death time of each animal were recorded.
Fatally poisoned animals died between 136 minutes and 24 hours post-administration with following clinical signs: squatting position, ruffled fur, disturbance of balance, abdominal position and passivity. - Clinical signs:
- other: Surviving animals showed same symptoms in an attenuated form, and were free of symptoms 48 hours post administration. Animal behavior was normal throughout the study period.
- Gross pathology:
- The autopsy of all animals (dead during the study and euthanased) showed no signs of macroscopic alterations.
Any other information on results incl. tables
Table 07.02.02_01. Mortality
Dose | Concentration | Number of death animals / |
(mg/kg) | (%) | Number of used animals |
80 | 5 | 0/10 |
125 | 5 | 2/10 |
200 | 5 | 5/10 |
315 | 5 | 10/10 |
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral media lethal dose (LD 50) in female rats is 180 mg/kg body weight. The confidence interval for p=0.05 is 151 - 215 mg/kg body weight.
- Executive summary:
- The examination of acute oral toxicity was performed on female Wistar rats by oral gavage at the doses 80, 125, 200 and 315 mg/kg bodyweight. At the end of an observation period of 14 days a LD 50 of 180 (151 - 215) mg/kg body weight was determined by Probit.
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