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Diss Factsheets
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EC number: 604-394-0 | CAS number: 144086-02-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No experimental toxicokinetic study is available on 2,2-bis(hydroxymethyl)-1,3-propanediol, ethoxylated and propoxylated, esters with acrylic acid. However, as per REACH guidance document R7.C (May 2008), information on absorption, distribution, metabolisation and excretion may be deduced from the physicochemical properties.
Oral absorption could be observed at high concentrations, but a low absorption of 2,2-bis(hydroxymethyl)-1,3-propanediol, ethoxylated and propoxylated, esters with acrylic acid after dermal or inhalation exposure is expected.
Key value for chemical safety assessment
Additional information
No experimental toxicokinetic study is available on 2,2-bis(hydroxymethyl)-1,3-propanediol, ethoxylated and propoxylated, esters with acrylic acid. However, as per REACH guidance document R7.C (May 2008), information on absorption, distribution, metabolisation and excretion may be deduced from the physicochemical properties, including:
-Range of molecular weight: 488 -630 g/mol
-Water solubility: 1.38 mg/L (20°C)
-Partition coefficient Log Kow: 1.73-3.11
-Vapour pressure: 0,0000667 Pa
ABSORPTION
The value of log Kow (between 1.7 and 3.11) is in the range suggestive of favourable absorption from the gastro-intestinal tract subsequent to oral ingestion, despite a low water solubility. This assumption of an oral absorption is confirmed in the acute toxicity studies: systemic effects (e.g. piloerection) were observed in rats treated at 2000 mg/kg bw, and mortalities occurred at the dose of 5000 mg/kg bw. Indeed, 2,2-bis(hydroxymethyl)-1,3-propanediol, ethoxylated and propoxylated, esters with acrylic acid can be absorbed by oral route at the high doses.
Log Kow between 2 and 3 is are optimal to have a good dermal absorption, however the low solubility can limit this absorption. Moreover, the acrylates are known to bind to skin components, and this binding decreases their dermal absorption. Experimental data suggest a low dermal absorption. In the dermal acute toxicity study, no systemic effect or mortality was observed in rats treated at 2000 mg/kg bw. And an analoguous substance of 2,2-bis(hydroxymethyl)-1,3-propanediol, ethoxylated and propoxylated, esters with acrylic acid showed no allergic reaction in the GMPT (skin sensitisation test on guinea pigs).
Based on the low value of the vapour pressure, 2,2-bis(hydroxymethyl)-1,3-propanediol, ethoxylated and propoxylated, esters with acrylic acid is not a volatile substance. Based on the low values of vapour pressure and water solubility, no absorption by inhalation is expected for this substance.
DISTRIBUTION and METABOLISM
The molecule is lipophilic (log Kow between 1.7 and 3.11), it is likely to distribute into cells and the intracellular concentration may be higher than extracellular concentration particularly in fatty tissues.
No specific data is available on the metabolism of 2,2-bis(hydroxymethyl)-1,3-propanediol, ethoxylated and propoxylated, esters with acrylic acid.
ELIMINATION
Due to the low water solubility and a moderate molecular mass (between 200 and 1000 g/mol),the excretion of 2,2-bis(hydroxymethyl)-1,3-propanediol, ethoxylated and propoxylated, esters with acrylic acid in the urines is not expected. An excretion via bile and faeces is possible.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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