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EC number: 266-113-4 | CAS number: 66071-94-1 Substance obtained by the partial removal of water from the liquid resulting from steeping corn in a water and sulphur dioxide solution which is allowed to ferment by the action of naturally occurring lactic acid-producing microorganisms.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 1941
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study without detailed documentation, for a read-across substance.
Data source
Reference
- Reference Type:
- publication
- Title:
- THE SINGLE DOSE TOXICITY OF SOME GLYCOLS AND DERIVATIVES
- Author:
- Smyth HF, Seaton J & Fischer L
- Year:
- 1 941
- Bibliographic source:
- Journal of Industrial Hygiene and Toxicology, 23(6): 259-268
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- - equivalent or similar to OECD Guideline 401; reliability scoring based on 2001 guideline
- Deviations:
- yes
- Remarks:
- - lack of details in experimental methods and results
- GLP compliance:
- no
- Remarks:
- - Study predates GLP requirements.
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Lactic acid
- EC Number:
- 200-018-0
- EC Name:
- Lactic acid
- Cas Number:
- 50-21-5
- Molecular formula:
- C3H6O3
- IUPAC Name:
- 2-hydroxypropanoic acid
- Details on test material:
- - Name of test material (as cited in study report): Lactic acid.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Commercial breeders; not specified.
- Age at study initiation: Not reported.
- Weight at study initiation: 90 to 120 g.
- Fasting period before study: Not reported.
- Housing: Not reported.
- Diet (e.g. ad libitum): The animals received an adequate diet of Purina chows, supplemented by fresh vegetables. The diet was given in the afternoon.
- Water (e.g. ad libitum): Water (source not specified), ad libitum.
- Acclimation period: Not reported.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported.
- Humidity (%): Not reported.
- Air changes (per hr): Not reported.
- Photoperiod (hrs dark / hrs light): Not reported.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: Not reported
- Amount of vehicle (if gavage): Not reported
- Justification for choice of vehicle: Not reported
MAXIMUM DOSE VOLUME APPLIED: Not reported - Doses:
- Maximum concentration of 5% (doses not specified).
- No. of animals per sex per dose:
- 10 males per dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days.
- Frequency of observations and weighing: Not reported.
- Necropsy of survivors performed: No.
- Other examinations performed: clinical signs, body weight, organ weights, histopathology, other: Any victims whose death was inconsistent with the indications from others receiving the same substance was autopsied, and if found to be infected, it was not included in the calculations. - Statistics:
- The data were calculated by the method of probits, described by Bliss (1935, 1938). No attempt was made to use adequate animals to obtain extreme precision in the LD50 figures, for the use to which such information is put seldom justifies extreme accuracy. The precision is indicated by the range of 95% probability listed in the tables.
Results and discussion
- Preliminary study:
- Not applicable.
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 3.73 other: g/kg bw
- 95% CL:
- 3.02 - 4.61
- Remarks on result:
- other: Slope = 4.04
- Mortality:
- Not reported.
- Clinical signs:
- other: Not reported.
- Gross pathology:
- Not reported.
- Other findings:
- Not reported.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: CLP (EC 1272/2008)
- Executive summary:
The work of this group pre-dates range finding toxicity guidelines and provided much of the basis for their development. Their results are cited by many subsequent authoritative review bodies and are often found in SIDS and SIAR documents via secondary references. Therefore, these results are deemed reliable.
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