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Diss Factsheets
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EC number: 204-375-3 | CAS number: 120-18-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
oral
LD50, rat; application per gavage: ca. 1400 mg/kg bw (mortalities due to local corrosive effects in the stomach; standardized test protocol, comp. to OECD 401; BASF AG 1972)
inhalative
no data available
dermal
no data available
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 400 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
There are valid data available for the assessment of the acute oral toxicity of naphthalene-2 -sulfonic acid.
oral
In an acute oral toxicity study following a standardized test protocol, technical pure naphthalene-2-sulfonic acid was administered per gavage in doses between 800 and 3200 mg/kg bw to groups of 5 male and 5 female rats (BASF AG 1972). The test substance was administered as 16% solution in water. The animals were observed for 14 d. The LD50 is ca. 1400 mg/kg bw. for males and females. Mortality and clinical signs appeared in doses >= 1000 mg/kg bw. Clinical signs associated with oral doses included dyspnea, convulsions and staggering. Postmortem examinations showed predominantly hemorrhagic slough eschar in the stomach in the animals that died and, to a lower extend, in surviving animals. Further observations at necropsy were congestive hyperemia, dilatation of the heart, hydrothorax, slight ascites, hemorrhagic slough eschar in the stomach and hematinic intestinal content in animals that died. Emaciation was observed in survivors in a dose-dependent manner. The dominant effect in animals that died seen at necropsy (hemorrhagic slough in the stomach) is a typical observation in the stomach after administration of acids per gavage. Mortalities are therefore considered primarily as consequence of the dominant local corrosion in the stomach.
This assessment is supported by results of two reliable studies with the noncorrosive sodium salts of nathalenesulfonic acids (BASF AG 1978, BASF AG 1964). In these studies, performed after the standard acute method with rats, the LD50 is >5000 mg/kg bw.
Inhalation
No experimental data were available. Due to the corrosive effects of the substance, there is no need for testing.
Dermal
No experimental data were available. Due to the corrosive effects of the substance, there is no need for testing.
Read across justification:
The registration item contains ca. 78.89% of naphthalene-2-sulphonic acid (CAS # 120-18-3) and ca. 6.5 % of naphthalene-1-sulphonic acid (CAS # 85-47-2). These two substances have the same molecular weight and are structurally almost identical. Therefore naphthalene-2-sulphonic acid and naphthalene-1-sulphonic acid and their respective salts are suitable for read across in order to fulfill the data requirements.
Justification for classification or non-classification
Based on the available acute oral and dermal toxicity studies, the substance was classified R22 (according to Directive 67/548/EEC) and Acute toxicity oral Cat 4 (according to CLP).
The available data on naphthalenesulfonic acids for acute oral toxicity indicates that mortalilty can be clearly attributed to the corrosive properties as respective salts had an LD50 > 5000 mg/kg bw. Mortality is caused by local effects and not systemic toxicity.
Data for the acute inhalative and dermal toxicity were not available. Due to the corrosive effects of the substance, there is no need for testing.
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