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EC number: 204-469-4 | CAS number: 121-44-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: acceptable well-documented publication which meets basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Embryotoxicity of Sixteen Industrial Amines to the Chicken Embryo
- Author:
- A. Korhonen, K. Hemminki and H. Vainio
- Year:
- 1 983
- Bibliographic source:
- JOURNAL OF APPLIED TOXICOLOGY, VOL. 3, NO. 2, 1983
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- White Leghorn chicken eggs were treated with triethylamine and observed for signs of toxicity and malformations. The affected embryos were classified into the categories, dysplaying the grade of effects.
- GLP compliance:
- no
- Type of method:
- in vivo
Test material
- Reference substance name:
- Triethylamine
- EC Number:
- 204-469-4
- EC Name:
- Triethylamine
- Cas Number:
- 121-44-8
- Molecular formula:
- C6H15N
- IUPAC Name:
- triethylamine
- Details on test material:
- Triethylamine of technical grade were obtained from Merck, Darmstadt.
Constituent 1
Test animals
- Species:
- other: White Leghorn chicken eggs
- Strain:
- not specified
Administration / exposure
- Route of administration:
- other: injection
- Type of inhalation exposure (if applicable):
- other: not applicable
- Vehicle:
- acetone
- Details on exposure:
- no details given
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- no details given
- Duration of treatment / exposure:
- The solution was injected into the egg in a total volume of 5 µl. Ten control eggs, injected with 5 µL of acetone, were incubated with each batch of eggs. Results from solvent controls were not subtracted from experimental values.
- Frequency of treatment:
- one-time
- Duration of test:
- The incubation was terminated 11 days after the injection, after a total incubation of 14 days. The remaining eggs were opened and the embryos inspected for survival and for external malformations.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.5, 1.0, 2.0, 4.0 µmol per egg
Basis:
other: injected
- No. of animals per sex per dose:
- 30 eggs for 0.5, 1.0 and 2.0 µmol; 20 eggs for 4.0 µmol
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- no further details on study design available
- Statistics:
- no details available
Results and discussion
Effect levels
open allclose all
- Dose descriptor:
- other: ED50
- Effect level:
- 0.9 other: µmol per egg (effect type : embryotoxicity)
- Basis for effect level:
- other: Malformations: small eye cup, defects of lids and cornea, encephalocoele or skin pimple in head, open coelom, short back or neck and defects of wings
- Dose descriptor:
- other: LD 50
- Effect level:
- 1.8 other: µmol per egg (effect type embryotoxicity)
- Basis for effect level:
- other: mortality
Any other information on results incl. tables
The embryotoxic potency of triethylamine including deaths and malformations, is defined by the total effect, i.e. the total number of affected embryos on day 14 of incubation (Table 1). LD50 values for total mortality on day 14 could also be calculated (Table 2).
Table 1. Embryotoxic effects |
||||||||||||
Treatment (µmol per egg) |
Treated embryos |
Early deaths (before day 5) |
Late deaths non-malformed embryos |
(Days 6-14) malformed embryos |
Malformed survivors (on day 14) |
All affected embryos |
||||||
(n) |
(%) |
(n) |
(%) |
(n) |
(%) |
(n) |
(%) |
(n) |
(%) |
|||
TEA |
|
|||||||||||
0.5 |
30 |
0 |
(0) |
0 |
(0) |
1 |
(3) |
6 |
(20) |
7 |
(23) |
|
1.0 |
30 |
6 |
(20) |
0 |
(0) |
2 |
(7) |
11 |
(37) |
19 |
(63) |
|
2.0 |
30 |
15 |
(50) |
0 |
(0) |
2 |
(7) |
4 |
(13) |
21 |
(70) |
|
4.0 |
20 |
19 |
(95) |
0 |
(0) |
0 |
(0) |
0 |
(0) |
19 |
(95) |
Table 2. ED50and LD50values of different embryotoxic effects of TEA on chick embryos |
|||||||
|
Total effect ED50(µmol per egg) |
95% confidence limits |
Total mortality |
Early deaths LD50 |
|||
|
(µmol per egg) |
Tanα |
(µmol per egg) |
Tanα |
(µmol per egg) |
Tanα |
|
TEA |
0.9 |
(0.65 - 1.2) |
0.98 |
1.6 |
1.5 |
1.8 |
1.2 |
Estimated from incomplete dose-response curves |
Applicant's summary and conclusion
- Conclusions:
- Triethylamine was one of the most potent chemicals that affected eggs
- Executive summary:
Sixteen amine compounds that are used in the rubber industry, including triethylamine were tested on three day chicken embryos for embryotoxicity. The parameters measured were: early deaths recorded within two days of injection, late deaths of malformed embryos, late deaths of non-malformed embryos and malformed survivors. Triethylamine was one of the chemicals which caused the highest frequencies of malformations.
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