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EC number: 204-469-4 | CAS number: 121-44-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation: BASF-Test "Industrial hygiene orientating investigation", report Nr. VI/389, 1960. The study is comparable to the OECD guideline 404. Rabbits, occlusive, undiluted, 1, 5, 15 min.
Eye irritation: BASF Test "Industrial hygiene orientating investigation", report Nr. VI/389, 1960. The study is comparable to the OECD Guideline 405. Rabbits, 50 µL.
Respiratory irritation: F. Gagnaire et al., 1989. Nasal Irritation and Pulmonary Toxicity of Aliphatic Amines in Mice. Journal of Applied Toxicology, Vol. 9(5), 301-304 (1989). Nasal exposed , Range of exposure concentrations 77-305 ppm.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin irritation
In the BASF skin irritation study (BASF, 1960), triethylamine was applied to the rabbit skin under occlusive condition for 1, 5 and 15 min. The animals were observed for 26 days. 1 min of exposure caused full thickness necrosis. The 24 -72 h scores revealed edema with necrosis. Triethylamine was corrosive to the rabbit skin. In a supporting study (Springborn Laboratories, 1989) similar effects in treated animals were observed. Meyers and Ballantyne exposed male rabbits dermally to small volume of triethylamine (0.01 mL) under uncovered conditions and to large volume (0.5 mL) occlusively during 4 hours. After 18 -24 hours unoccluded contact with small volume test material produced moderately erythema without necrosis. However, severe irritation with necrosis was recorded at the end of the 4 -h contact period and at 24 and 48 h following contact when dosed with large volumes under occlusive conditions.
Eye irritation
In the BASF eye irritation study (BASF, 1960), triethylamine was applied to rabbit eyes. The observations were recorded after 10 min, 1 and 3 hours. Thereafter, the animals were observed up to 19th day. Severe ocular injury was observed in rabbits treated with 0.050 mL undiluted triethylamine. Irreversible effects occurred after 10 min of exposure. Meyers and Ballantyne tested 0.005 mL of triethylamine on rabbit eyes (Meyers and Ballantyne, 1997). After 18 -24 hours the following observations were reported: severe corneal opacity, iritis, necrosis and hemorrhage of the eyelids, and chemosis. Similar findings were observed in the old studies. A corneal opacity and severe conjunctival inflammations with following necrosis developed promptly if 0.1 mL triethylamine was applied to the rabbit eyes. The effects persisted through several days and appeared to be not reversible (refer to eye irritation endpoints of the IUCLID file).
Respiratory irritation
In nasal irritation and pulmonary toxicity study of 20 aliphatic amines in mice, Gagnaire et al. (1989) exposed mice to airborne TEA to determine the RD50 value. This value indicates 50% decrease in the respiratory rate and is considered to be successfully used to predict safe industrial exposure. Mice were exposed nasal to a range of concentrations of triethylamine. The breathing frequency was used as an index of upper respiratory tract irritation. The onset of action of TEA was very rapid, ca. 30 sec. to 1 min. 156 ppm of TEA was determined as RD50 in mice. The tested concentrations produced a range of effects, whose severity was concentration dependent. At the end of a 15 -min exposure period, the recovery of respiratory frequencies to the pre-exposure values was also rapid, ca.1 min. Due to the rapid recovery of respiratory frequency in mice, triethylamine is considered to be moderately irritating to the upper respiratory and lower respiratory tract. The predicted safe levels to prevent upper airway irritation should not exceed 15 ppm for TEA. The effects of TEA were reversible in non-cannulated mice, but irreversible in tracheally cannulated mice (effects on the lower airways, can culminate in pulmonary congestion).
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Effects on respiratory irritation: highly irritating
Justification for classification or non-classification
Due to corrosive effects of TEA observed in treated animals in irritation studies, classification is warranted according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008:
According to GHS:Skin corr. Cat.1A; Eye damage Cat.1; STOT-SE Cat.3, respiratory irritating
According to DSD:C, R35 Corrosive; Causes severe burns.
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