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Diss Factsheets
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EC number: 234-123-8 | CAS number: 10543-57-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- short-term repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study cannot be subsumed under a testing guideline and was not performed in accordance with GLP, however, is well documented and scientifically acceptable. The investigation is rated as reliable with restrictions (data quality score 2).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Deviations:
- not applicable
- Principles of method if other than guideline:
- Wistar rats were exposed in inhalation chambers to TAED dust for 23 consecutive working days, 5 hours/day. Parameters examined included: mortality, body weight and body weight gain, macroscopical examination at necropsy, organ weights (liver and kidney ) and histopathological examination of the respiratory system, liver and kidneys.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- N,N'-ethylenebis[N-acetylacetamide]
- EC Number:
- 234-123-8
- EC Name:
- N,N'-ethylenebis[N-acetylacetamide]
- Cas Number:
- 10543-57-4
- Molecular formula:
- C10H16N2O4
- IUPAC Name:
- N,N'-ethylenebis[N-acetylacetamide]
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 5 hours/day for 23 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
141 mg/m3 on day 1, 145 mg/m3 on day 2 -10, 212 mg/ m3 on day 11 -15 and 508 mg/ m3 on day 16 -23; mean TAED concentration of 283 mg/m3 calculated for the total treatment period
Basis:
nominal conc.
- No. of animals per sex per dose:
- 10 males and 10 females
- Control animals:
- yes
Results and discussion
Effect levels
- Dose descriptor:
- NOAEC
- Effect level:
- >= 283 mg/m³ air
- Sex:
- male/female
- Basis for effect level:
- other: no adverse effects observed
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
RS-Freetext:
All animals survived the exposure period.The body weights and body weight gains of the treated animals did not differ from the control rats. According to the study report, clinical signs were not recorded during the treatment period. No macroscopically visible changes were observed at necropsy. Liver and kidney weights, which were the only organ weights determined, were comparable to control. Histopathological examination of the respiratory system, liver and kidneys revealed no substance related effects.
Applicant's summary and conclusion
- Executive summary:
Subacute inhalation toxicity was evaluated in 10 male and 10 female Wistar rats exposed in inhalation chambers to TAED dust for 23 consecutive working days, 5 hours/day, at levels of 141 mg/m3 on day 1, 145 mg/m3 on day 2-10, 212 mg/ m3 on day 11-15 and 508 mg/ m3 on day 16-23. A mean TAED concentration of 283 mg/m3 was calculated for the total treatment period. A control group of 10 male and 10 female animals was included in the study. All animals survived the exposure period. The body weights and body weight gains of the treated animals did not differ from the control rats. According to the study report, clinical signs were not recorded during the treatment period. No macroscopically visible changes were observed at necropsy. Liver and kidney weights, which were the only organ weights determined, were comparable to control. Histopathological examination of the respiratory system, liver and kidneys revealed no substance-related effects.
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