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EC number: 204-435-9 | CAS number: 120-92-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The used protocol was the method published by the OECD. However, the purity of the test substance was not noted and the GLP were not mentioned. The number of scores were not detailed.
Data source
Reference
- Reference Type:
- publication
- Title:
- Evaluation of the ocular-irritation potential of 56 compounds
- Author:
- Guillot JP, Gonnet JF, Clement C, Caillard L, Truhaut R
- Year:
- 1 982
- Bibliographic source:
- Food Chem Toxicol, 20, 573-582
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cyclopentanone
- EC Number:
- 204-435-9
- EC Name:
- Cyclopentanone
- Cas Number:
- 120-92-3
- Molecular formula:
- C5H8O
- IUPAC Name:
- cyclopentanone
- Details on test material:
- no data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS:
- Source: Roucher SA, Couhé
- Weight at study initiation: about 2.5 kg
- Age at study initiation, housing, diet, water, acclimation period data not available
ENVIRONMENTAL CONDITIONS (temperature, humidity, air changes, photoperiod): data not available
IN-LIFE DATES: data not available
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the other eye served as control
- Amount / concentration applied:
- undiluted
Amount applied: 0.1 ml - Duration of treatment / exposure:
- not rinsed or rinsed after 4 and 30 s
- Observation period (in vivo):
- observation at 1 h, 1, 2, 3, 4 and 7 days after instillation and, in case where lesion persisted, also at later stages
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- - Removal of test system: washing with Dacryoserum after 4 or 30 s (or not rinsed)
- Scoring system: at each observation time, lesions of the conjonctiva, iris and cornea were recorded separately using a numerical system based on that of Kay & Calandra (1962), the sum of these scores being the individual ocular irritation index (IOI) of each animal. Calculation of the mean of the IOI values (over six rabbits) gave the mean ocular irritation index (MOI). The greatest MOI obtained over the range of observation times was identified as the acute ocular irritation index (AOI; corresponding to the OECD approach) which was used for the classification of the substance in one of six categories between "non-irritant" and "extremely irritant" (AFNOR scale). The maximum value of index is 110.
- Tool used to assess score: data not available
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: AOI
- Score:
- 54.33
- Max. score:
- 110
- Reversibility:
- not specified
- Remarks on result:
- other: see results below
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
Any other information on results incl. tables
- Irritation score:
Rinsing AOI (*) MOI IOI
procedure
None 54.33 43.67 [d7] > 30 (d4)
30 sec 49.67 17.50 [d7] > 30 (d1)
4 sec 54.66 20.67 [d7]
*: the AOI was the 24-hr MOI
- Remarks: Cyclopentanone is considered as "severely irritant" according
to the AFNOR quotation since:
- IOI at day 7 was > 30 without rinsing (for 4 rabbits / 6
rabbits) and with rinsing at 30 seconds (1 rabbit / 3 rabbits).
- MOI after 7 days was 43.67 without rinsing, 17.50 after
rinsing at 30 seconds and 20.67 after rinsing at 4 seconds.
- AOI = 54.33 of the OECD approach without rinsing
procedure. After rinsing at 30 or 4 seconds, AOI (at 24
hours) was 49.67 or 54.66 respectively.
Rinsing reduced the severity of the eye lesions and even
affected a significant reversibility by day 14 or 21,
although rinsing at 4 or 30 seconds did not change the classification.
Applicant's summary and conclusion
- Interpretation of results:
- other: Irritating to the eye. Classified as irritant in the annex VI 3.2 of the CLP regulation 1272/2008
- Conclusions:
- Irritating to the eye.
Classified as irritant in the annex VI 3.2 of the CLP regulation 1272/2008 - Executive summary:
In a primary eye irritation study [Guillot, 1982], 0.1 mL of undiluted cyclopentanone (purity unknown) was instilled into the conjunctival sac of the eye of New Zealand White rabbits (6/group). The eyes were not rinsed, or rinsed after 4 or 30 sec. Animals then were observed for at least 7 days. Irritation was scored by the method of Kay & Calandra, and using the AFNOR scale.
In this study, cyclopentanone was irritating to the eye.
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