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Diss Factsheets
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EC number: 201-842-3 | CAS number: 88-60-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Reproduced from SIAR 6-tert-Butyl-m-cresol, 08.08.2002
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- 5 male and 5 female rats received a single oral application per gavage of 0, 130, 320, 800 or 2000 g/kg bw of the test substance. Post-exposure period was 14 days.
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- 6-tert-butyl-m-cresol
- EC Number:
- 201-842-3
- EC Name:
- 6-tert-butyl-m-cresol
- Cas Number:
- 88-60-8
- Molecular formula:
- C11H16O
- IUPAC Name:
- 2-tert-butyl-5-methylphenol
- Details on test material:
- produced by Sumitomo Chemical Co., Ltd. Purity 99.23 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- 0, 130, 320, 800, 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- yes
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- >= 130 - <= 320 mg/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 320 - <= 800 mg/kg bw
- Mortality:
- male rats: dose 0 mg/kg bw, mortality 0/5; dose 130 mg/kg bw, mortality 0/5; dose 320 mg/kg bw, mortality 0/5; dose 800/kg bw, mortality 4/5; dose 2000 mg/kg bw, mortality 3/5
female rats: dose 0 mg/kg bw, mortality 0/5; dose 130 mg/kg bw, mortality 0/5; dose 320/kg bw, mortality 3/5; dose 800 mg/kg bw, mortality 4/5; dose 2000 mg/kg bw, mortality 4/5 - Clinical signs:
- other: hypoactivity, a prone or lateral position and soiled fur in 800 mg/kg or in males and 130 mg/kg or more in females. Bradypnea and Cheyne-Strokes' respiration in moribund animals of both sexes. Hypothermia, clonic convulsion, ataxic gait and vocalisation i
- Gross pathology:
- pathological lesions were observed in the digestive organ and kidneys
- Other findings:
- no data
Any other information on results incl. tables
Cumulative Daily Mortality
Male
Dose(mg/kg) Cum. Mortal. Time of death
0 0/5
130 0/5
320 0/5
800 4/5 d1:1an, d2:3an
2000 3/5 d2:2an, d3:1an
Female
Dose(mg/kg) Cum. Mortal. Time of death
0 0/5
130 0/5
320 3/5 d2:3an
800 4/5 d1:1an, d2:3an
2000 4/5 d2:4an
Cum. Mortal.; Cumulative Mortality; No. of animals which dead/ No. of animals used an; animal, d; day
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information
- Executive summary:
method: 5 male and 5 female rats received a single oral application per gavage of 0, 130, 320, 800 or 2000 g/kg bw of the test substance. Post-exposure period was 14 days.
result: LD50 = 130 -320 mg/kg bw (rat, female), LD50 = 320 -800 mg/kg bw (rat, male)
reference: MHW, Japan (1999)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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