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EC number: 210-871-0 | CAS number: 624-92-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: National Standard of the People’s Republic of China Toxicological Test Methods of Pesticides for Registration (GB 15670-1995)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- 4 rats/sex
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Dimethyl disulphide
- EC Number:
- 210-871-0
- EC Name:
- Dimethyl disulphide
- Cas Number:
- 624-92-0
- Molecular formula:
- C2H6S2
- IUPAC Name:
- (methyldisulfanyl)methane
- Test material form:
- liquid: volatile
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River, Raleigh NC
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation:
- Weight at study initiation: 307 – 340 g for males and 216 - 236 g for females.
- Fasting period before study: no
- Housing: individually housed in suspended stainless steel wire bottom cages
- Diet: ad libitum fresh PMI Rat Chow (Diet #5012)
- Water: ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- temperature controlled
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: The clipped area began at the shoulders and extended to the hipbone and half way down the flank of each side of the animal
- % coverage: 10
- Type of wrap if used: porous dressing to retain the gauze dressing (semi-occlusive) and porous non-irritating tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): room temperature distilled water
- Time after start of exposure: 4h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.54-0.60 ml/rat
- Constant volume or concentration used: no - Duration of exposure:
- 4 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 4
- Control animals:
- no
- Details on study design:
- Animals were observed at 4 hours post-dosing on Day 0 and once daily thereafter for 14 days. Observations included, but were not limited to, evaluation of skin and fur, eyes and mucous membranes, respiratory and circulatory effects, autonomic effects such as salivation, central nervous system effects including tremors and convulsions, changes in the level of activity, gait and posture, reactivity to handling or sensory stimuli, altered strength, and stereotypies or bizarre behavior (e.g., self-mutilation, walking backwards). All animals were observed twice daily for mortality on Days 1 through 14.
Body weights were recorded pretest, Day 7 and at termination.
All animals were humanely sacrificed using CO2 following study termination and were examined for gross pathology. Additional signs were described. - Statistics:
- None
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- All four males and four females survived, following the 4-hour dermal exposure at 2000 mg/kg.
- Clinical signs:
- other: Abnormal physical signs including wetness of the anogenital area was observed.
- Gross pathology:
- The gross necropsy revealed no observable abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The dermal LD0 of Dimethyl disulfide is greater than 2000 mg/kg in rats.
- Executive summary:
The dermal toxicity of Dimethyl Disulfide was evaluated in a study performed following the National Standard of the People’s Republic of China Toxicological Test Methods of Pesticides for Registration (GB 15670-1995), which is similar to the OECD TG 402. This study was conducted in accordance with current Good Laboratory Practice Regulations of the US EPA. Four healthy male and four healthy female Sprague Dawley rats were dosed dermally with Dimethyl disulfide at 2000 mg/kg of body weight. The test article was kept in contact with the skin for 4 hours at which time the wrappings were removed. Animals were observed at 4 hours post-dosing on Day 0 and once daily thereafter for 14 days. Observations included, but were not limited to, evaluation of skin and fur, eyes and mucous membranes, respiratory and circulatory effects, autonomic effects such as salivation, central nervous system effects including tremors and convulsions, changes in the level of activity, gait and posture, reactivity to handling or sensory stimuli, altered strength, and stereotypies or bizarre behavior (e.g., self-mutilation, walking backwards). All animals were observed twice daily for mortality on Days 1 through 14. Body weights were recorded pretest, Day 7 and at termination. All animals were examined for gross pathology.
All four males and four females survived, following the 4-hour dermal exposure at 2000 mg/kg. Abnormal physical signs including wetness of the anogenital area was observed. All eight animals gained body weight by study termination. The gross necropsy revealed no observable abnormalities.
The dermal LD0 of Dimethyl disulfide is greater than 2000 mg/kg in rats.
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