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Diss Factsheets
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EC number: 202-992-2 | CAS number: 101-96-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
For long term toxicity to Daphnia, test results from hydroquinone, one of the main hydrolysis products of 44PD, were used. Toxicity was investigated in a study conducted according to OECD Guideline 211 (Daphnia magna Reproduction Test) under GLP. Effect parameters observed were inhibition of reproduction, cumulative number of surviving offspring, first day of birth, death and body length of parent daphnias, occurrence of aborted eggs and male individuals. A 21 d NOEC=0.0057 mg HQ/L based on recalculated measured initial concentration was found. After correction for molecular weight, this corresponds to a 21 d NOEC of 0.114 mg 44PD/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.011 mg/L
Additional information
For 44PD read-across is done from hydroquinone (HQ). The long-term toxicity of hydroquinone was investigated in a study conducted according to OECD Guideline 211 (Daphnia magna Reproduction Test) under GLP. Daphnids were exposed to nominal concentrations of 0 (control), 0.0081, 0.016, 0.033, 0.065, and 0.13 mg HQ/L under semi-static conditions with a 24 hour renewal period of the test water. The test concentrations were monitored via HPLC/UV in three exposure periods on days 0 -1, 10 -11 and 20 -21. The mean values of the measured initial concentrations were 0.0057. 0.012, 0.027, 0.054 and 0.106 mg HQ/L. Effect parameters observed were inhibition of reproduction, cumulative number of surviving offspring, first day of birth, death and body length of parent daphnias, occurrence of aborted eggs and male individuals. A 21 d NOEC=0.0057 mg HQ/L based on recalculated measured initial concentration was found. This corresponds to a 21d NOEC of 0.0114 mg 44PD/L. The testing/validity criteria laid down in the OECD guideline 211 are fulfilled. This study is regarded as reliable without restriction.
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