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Diss Factsheets
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EC number: 214-130-2 | CAS number: 1091-93-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Mar - Apr 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to OECD guideline under GLP
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Principles of method if other than guideline:
- not relevant
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-methoxyestra-2,5(10)-dien-17β-ol
- EC Number:
- 214-130-2
- EC Name:
- 3-methoxyestra-2,5(10)-dien-17β-ol
- Cas Number:
- 1091-93-6
- Molecular formula:
- C19H28O2
- IUPAC Name:
- (1S,3aS,3bR,9bS,11aS)-7-methoxy-11a-methyl-1H,2H,3H,3aH,3bH,4H,5H,6H,9H,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-ol
- Details on test material:
- - Name of test material (as cited in study report): Dihydro-Estradiol-Methylether
- Analytical purity: 89.7%
- Lot/batch No.: 21400234-35
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 0.03 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
Any other information on results incl. tables
- Sublethal observations / clinical signs:
Table 1: Cumulative mortality (dead fish in percent)
Test dilutions Concentration (mg/L) 24 hours 48 hours 72 hours 96 hours ControI 0 0 0 0 0 1:8 0,01 0 0 0 0 1 :4 0,02 0 0 0 0 1 :2 0,03 0 10 20 40 Saturated solution 0,13 10 80 80 100
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The LC50/96 hours of Dihydro-Estradiol-Methylether in Zebra fish was 0.03 mg/L (a confidence limit could not be
calculated). Therefore, the test item is very toxic to fish. - Executive summary:
Ten Zebra fish were used for each of the test solutions and ten for the control group. The fish were exposed to 4 different concentrations of Dihydro-Estradiol-Methylether (1 :8-, 1 :4-, 1 :2-, and the saturated solution) and tap water (controI) for a period of 96 hours. Mortalities and visible abnormalities were recorded at approximately 3, 6, 24, 48, 72 and 96 hours. Samples for the concentration analysis by HPLC were taken at 0, 48 and 96 hours. The mean measured concentrations were 0.13 mg/L (saturated solution) and 0.03 mg/L (1 :2-dilution). The 1 :4- and 1 :8-dilutions of test item were below the detection limit. 100% mortality was observed in the highest test concentration (saturated solution). Furthermore, 40% mortality was the result of exposing the fish to the 1:2 dilution of the saturated solution. No further mortality was observed in the other test concentrations or the control during the whole exposure time.
The LC50/96 hours of Dihydro-Estradiol-Methylether in Zebra fish was 0.03 mg/L (a confidence limit could not be calculated). Therefore, the test item is very toxic to fish.
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