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EC number: 204-642-4 | CAS number: 123-68-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Pre-GLP, pre-OECD TG study with sufficient detail in documentation, but volatilisation of test substance from food was not considered
Data source
Reference
- Reference Type:
- publication
- Title:
- Food flavorings and compounds of related structure. II. Subacute and chronic toxicity
- Author:
- Hagan EC, Hansen WH, Fitzhugh OG, Jenner PM, Jones WI, Taylor JM, Long EL, Nelson AM and Brouwer JB
- Year:
- 1 967
- Bibliographic source:
- Food and Cosmetics Toxicology, 5(2), 141-157
Materials and methods
- Principles of method if other than guideline:
- The study was conducted prior to the publication of OECD TGs. Rats received the test substance via for a period of 52 weeks.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Allyl hexanoate
- EC Number:
- 204-642-4
- EC Name:
- Allyl hexanoate
- Cas Number:
- 123-68-2
- Molecular formula:
- C9H16O2
- IUPAC Name:
- allyl hexanoate
- Details on test material:
- Name: Allyl caproate (allyl hexanoate)
Purity: commercial product
No further details provided
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Osborne-Mendel
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: not reported
- Age at study initiation: weanling
- Weight at study initiation: not reported
- Fasting period before study: not reported
- Housing: individually in wire cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: not reporte
ENVIRONMENTAL CONDITIONS
- not reported
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- DIET PREPARATION
- Rate of preparation of diet (frequency): fresh diets were prepared weekly
- Mixing appropriate amounts with (Type of food): not reported
- Storage temperature of food: not reported - Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 52 weeks
- Frequency of treatment:
- Continuously (animals had free access to food)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2500 ppm
Basis:
nominal in diet
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- yes, plain diet
- Details on study design:
- - Dose selection rationale: not reported
- Positive control:
- No
Examinations
- Observations and examinations performed and frequency:
- Body weight, food intake and general conditions: every week
Haematology (white cell count, red cell count, haemoglobins, haematocrits): after 3, 6 12 months
Gross pathology: at termination of study
Histopathology: at termination of study - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes
HISTOPATHOLOGY: Yes - Other examinations:
- Not reported
- Statistics:
- Not reported
Results and discussion
Results of examinations
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- no effects observed
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- no effects observed
- Histopathological findings: neoplastic:
- no effects observed
- Details on results:
- No adverse effects were observed/reported.
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- > 2 500 mg/kg diet
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: No effects observed/reported
- Dose descriptor:
- NOAEL
- Effect level:
- > 214 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: based on 30 g/day food consumption and 350 g/rat body weight
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Oral repeated exposure of rats to allyl hexanoate in food at a concentration of 2500 ppm (mg/kg food) over a period of one year had no adverse effects on male and female rats.
- Executive summary:
The repeated oral dose toxicity of allyl hexanoate to male and female Osborne-Mendel rats was studied over a period of 1 year. Five males and five females were fed food containing the test substance at a level of 2500 ppm (mg/kg food). Animals had free access to food over the whole study period. The body weight, food consumption and general condition of animals were recorded regularly. Haematological investigations were performed after 3, 6 and 12 months. At the end of the study all animals were sacrificed. Gross pathology was performed on every rat and organs were weighed. Sections were prepared from relevant organs for histopathological studies, which were performed for a representative fraction of animals in high dose and control groups evenly divided by sex. No adverse effects were observed during or at the end of the study at a dose level of 2500 mg/kg food.
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