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EC number: 236-004-6 | CAS number: 13092-66-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Testing was conducted between 30 September 2009 and 02 December 2009.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of inspection: 15 September 2009 Date of Signature: 26 November 2009
- Type of method:
- flask method
- Water solubility:
- >= 221 g/L
- Temp.:
- 20 °C
- Remarks on result:
- other: pH was depedent upon the loading rate of the test material.
- Details on results:
- Please see section Remarks on results including tables and figures.
- Conclusions:
- Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The water solubility of the test material has been determined to be at least 221 g/l of solution at 20.0 ± 0.5°C, using the flask method, Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008. However, the solubility of the test material was demonstrated to be extremely sensitive to the nominal loading rate of the solution, as demonstrated by the results in the following table:
Nominal loading rate (g/l) Equivalent test material concentration (g/l) Typical solution pH
5.0 3.68 5.2 to 5.7
16.7 11.5 4.5 to 5.2
50 36.1 3.9
100 67.6 3.7
200 117 3.4
400 221 3.0
Investigation into the influence of the pH range 4 to 9 on the solubility of the test material was performed, but in each case the test material demonstrated acidic characteristics on dissolution, overwhelming the capacity of the buffer solutions to give solution pH’s approximately equal to those observed using un-buffered water. Therefore, as the buffering capacity of the solutions used was considered to exceed that of the environment, the solubility of the test material was considered to be independent of the initial pH range 4 to 9, resulting in a consistent acidic solution capable of overwhelming any weak to moderate buffering capacities present.
Finally, although a definitive value for water solubility could not be determined, testing carried out did indicate that the influence of temperature on the observed solubility was not significant.
This study is considered to be adequate and reliable for the purpose of registration under REACH (Regulation (EC) No. 1907/2006). - Executive summary:
Method
The determination was carried out using the flask method, Method A6 Water Solubility ofCommissionRegulation (EC) No 440/2008 of 30 May 2008.
Conclusion
The water solubility of the test material has been determined to be in the range4.18 x 10-2to 4.89 x 10-2g/l of solution at 20.0 ± 0.5°C,using the flaskthod, Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008.
The effect of temperature over the range 10 to 30°C has been considered not to have had a significant influence on the solubility of the test material (range 3.72 x 10-2to 4.89 x 10-2g/l).
An assessment of the solubility of the test material over the environmentally relevant pH range of 4 to 9 gave similar solubility results at a solution pH in the range 8.2 to 9.1; however, at a solution pH of 7.2, the water solubility of the test material was much higher. Thus, the effect of pH has been considered to have had a significant effect on the solubility of the test material.
Reference
Results
Preliminary test
The preliminary estimate of water solubility was 3.33 g/l of solution.
Definitive test
The mean peak areas relating to the standard and sample solutions are shown in the following table:
Table 9
Solution |
Mean peak area |
Standard 30.0 mg/l |
3.771 |
Standard 30.6 mg/l |
3.924 |
Sample 7A |
2.034 |
Sample 7B |
2.043 |
Sample 6A |
2.071 |
Sample 6B |
2.060 |
Sample 1A |
2.012 |
Sample 1B |
1.993 |
Standard 30.0 mg/l |
3.773 |
Standard 30.6 mg/l |
3.921 |
Sample 3A |
2.001 |
Sample 3B |
2.019 |
Sample 2A |
1.954 |
Sample 2B |
1.989 |
Standard 30.0 mg/l |
3.762 |
Standard 30.6 mg/l |
3.891 |
Sample 4A |
2.142 |
Sample 4B |
2.147 |
Sample 5A |
1.982 |
Sample 5B |
1.994 |
Test for loading rate dependency
The mean peak areas relating to the standard and sample solutions are shown in the following table:
Table 10.
Solution |
Mean peak area |
Standard 47.1 mg/l |
6.037 |
Standard 47.2 mg/l |
5.959 |
Sample 8A |
6.721 |
Sample 8B |
6.087 |
Sample 9A |
6.690 |
Sample 9B |
5.116 |
Sample 10A |
6.750 |
Sample 10B |
6.718 |
Standard 47.1 mg/l |
6.092 |
Standard 47.2 mg/l |
6.013 |
Sample 11A |
6.746 |
Sample 11B |
6.664 |
Sample 12A |
6.637 |
Sample 12B |
6.390 |
Sample 13A |
6.527 |
Sample 13B |
6.406 |
Sample 14A |
6.208 |
Sample 14B |
6.349 |
Additional testing
The mean peak areas relating to the standard and sample solutions are shown in the following table:
Table 11.
Solution |
Mean peak area |
Standard 30.8 mg/l |
3.899 |
Standard 30.7 mg/l |
3.902 |
Sample 15A1 |
1.970 |
Sample 15B1 |
2.013 |
Sample 16A1 |
3.744 |
Sample 16B1 |
3.724 |
Standard 30.8 mg/l |
3.910 |
Standard 30.7 mg/l |
3.912 |
Sample 17A1 |
1.283 |
Sample 17B1 |
1.313 |
Sample 18A1 |
2.444 |
Sample 18B1 |
2.445 |
Overall results for the definitive test, the test for loading rate dependency and the additional testing
The concentration (g/l) of test material in the sample solutions is shown in the following table:
Table 12.
Nominal loading rate (g/l) |
Sample Number |
Time shaken at ~ 30ºC (hours) |
Time equilibrated at 20ºC (hours) |
Concentration (g/l) |
Solution pH |
5.0 |
1 |
72 |
24 |
3.62 |
5.5 |
6 |
48 |
24 |
3.74 |
5.2 |
|
7 |
24 |
24 |
3.69 |
5.7 |
|
2 |
72 |
24 [30°C] |
3.57 |
5.4 |
|
3 |
72 |
24 [10°C] |
3.64 |
5.5 |
|
4 |
72 |
24 |
3.90 |
4.9 |
|
5 |
72 |
24 |
3.62 |
5.7 |
|
16.7 |
8 |
72 |
24 |
11.6 |
4.5 |
13 |
48 |
24 |
11.6 |
5.2 |
|
14 |
24 |
24 |
11.2 |
5.2 |
|
9 |
72 |
24 [30°C] |
10.7 |
4.6 |
|
10 |
72 |
24 [10°C] |
12.2 |
4.6 |
|
11 |
72 |
24 |
12.1 |
4.9 |
|
12 |
72 |
24 |
11.7 |
5.3 |
|
50 |
15 |
72 |
24 |
36.1 |
3.9 |
100 |
16 |
72 |
24 |
67.6 |
3.7 |
200 |
17 |
72 |
24 |
117 |
3.4 |
400 |
18 |
72 |
24 |
221 |
3.0 |
The relationship between nominal loading concentration (g/l) and the resulting analysed equivalent test material concentration (g/l), for the un-buffered water samples, is shown in Figure 5.1. (attached).
The water solubility of the test material has been determined to be at least 221 g/l, although observed solubility was extremely sensitive to loading rate.
Validation
The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 0 to 100 mg/l*. This was satisfactory with a correlation coefficient of 1.000 being obtained. This work was performed under Harlan Laboratories Ltd Project Number 2920/0020.
Discussion
Even though excess undissolved test material was observed in all of the samples prepared as part of the definitive test, a decision was made to carry out a test for loading rate dependency at a higher loading rate; this was done since loading rate dependency was suspected. Subsequently, the results for this test confirmed loading rate dependency; therefore, it was decided to carry out additional testing at much higher loading rates.
No significant peaks were observed at the approximate retention time of the test material on analysis of any blank solutions.
All peaks observed in the relevant matrix blank chromatograms were also observed in the sample chromatograms. Any additional peaks in the samples, other than the analyte peak, were considered to be most likely due to water-soluble (ionic) impurities in the test material.
The use of sub-micron filtration was sometimes necessary to yield clear sample solutions which were visually free from undissolved test material. However, the use of filtration was determined to have a negligible effect on the concentration of test material in filtered solutions compared to unfiltered solutions. This work was performed under Harlan Laboratories Ltd Project Number 2920/0020.
The ion chromatography method applied directly quantified the dissolved phosphate content of each sample solution and these have been corrected to equivalent test material concentrations based on the theoretical phosphate content of the test material.
Description of key information
The water solubility of magnesium bis(dihydrogenorthophosphate) was determined according to EU Method A.6 (Water solubility) and under the conditions of GLP.
Key value for chemical safety assessment
- Water solubility:
- 221 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test material has been determined to be at least 221 g/l of solution at 20.0 ± 0.5°C. However, the solubility of the test material was demonstrated to be extremely sensitive to the nominal loading rate of the solution, as demonstrated by the results in the following table:
Nominal loading rate (g/l) |
Equivalent test material concentration (g/l) |
Typical solution pH |
5.0 |
3.68 |
5.2 to 5.7 |
16.7 |
11.5 |
4.5 to 5.2 |
50 |
36.1 |
3.9 |
100 |
67.6 |
3.7 |
200 |
117 |
3.4 |
400 |
221 |
3.0 |
Investigation into the influence of the pH range 4 to 9 on the solubility of the test material was performed, but in each case the test material demonstrated acidic characteristics on dissolution, overwhelming the capacity of the buffer solutions to give solution pH’s approximately equal to those observed using un-buffered water. Therefore, as the buffering capacity of the solutions used was considered to exceed that of the environment, the solubility of the test material was considered to be independent of the initial pH range 4 to 9, resulting in a consistent acidic solution capable of overwhelming any weak to moderate buffering capacities present.
Finally, although a definitive value for water solubility could not be determined, testing carried out did indicate that the influence of temperature on the observed solubility was not significant.
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