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Diss Factsheets
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EC number: 205-575-3 | CAS number: 142-96-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1954
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well performed study, study performance before implementation of GLP, purity of test item not reported
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity data, List V
- Author:
- Smyth, H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C.
- Year:
- 1 954
- Bibliographic source:
- Arch. Ind. Hyg. Occup. Med., 10, 61-68
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dibutyl ether
- EC Number:
- 205-575-3
- EC Name:
- Dibutyl ether
- Cas Number:
- 142-96-1
- Molecular formula:
- C8H18O
- IUPAC Name:
- 1-butoxybutane
- Details on test material:
- dibutyl ether (purity not indicated)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: raised at Mellon Institute of Industrial Research
- Age at study initiation: young adults
- Weight at study initiation: 90-120 grams
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- The stream was prepared by various styles of proportioning pumps. Nominal concentrations were recorded, not confirmed by analytical methods. Exposures were four hours long. Concentrations were in an essentially logarithmic series with a factor of two.
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- other
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- Groups of six male Carworth-Wistar rats (90 to 120 g), raised at the Mellon Institute of Industrial Research, University of Pittsburgh, USA, were exposed to a flowing stream of known vapor concentrations of dibutyl ether. The stream was prepared by various styles of proportioning pumps. Nominal concentrations were recorded, not confirmed by analytical methods. Exposures were four hours long. Concentrations were in an essentially logarithmic series with a factor of two. The concentration yielding fractional mortality among six rats within 14 days was recorded. Clinical signs were not reported.
- Statistics:
- no information available
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Sex:
- male
- Dose descriptor:
- other: approximate LC50
- Effect level:
- ca. 21 600 mg/m³ air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: approximately 4000 ppm
- Mortality:
- The 4-hour exposure to 4000 ppm dibutyl ether killed 2/6 rats within 14 days.
- Clinical signs:
- other: no information available
- Body weight:
- no information available
- Gross pathology:
- no information available
- Other findings:
- no information available
Any other information on results incl. tables
4000 ppm are at 25 °C and 1013 hPa equal to 21600 mg/m³.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The 4-hour exposure to 4000 ppm dibutyl ether killed 2/6 rats within 14 days. This substance is not classified for Acute toxicity
- Executive summary:
In this study, groups of six male Carworth-Wistar rats (90 -120 grams) were exposed to a flowing stream of known vapour concentrations of dibutyl ether for 4 hours. Under the conditions of the study, the 4-hour exposure to 4000 ppm dibutyl ether killed 2/6 rats within 14 days and this substance is not classified for Acute toxicity.
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