Aluminium, 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonic acid complex

Endpoint summary

Description of key information

Bioaccumulation: aquatic / sediment

BCFBAF model (v3.01) of Estimation Programs Interface (EPI Suite, 2017) was used to predict the bioconcentration factor (BCF) of test chemical aluminium, 6 -hydroxy-5 -[(4 -sulfophenyl)azo]-2 -naphthalenesulfonic acid complex (CAS No. 15790 -07 -5). The bioconcentration factor (BCF) of aluminium, 6 -hydroxy-5 -[(4 -sulfophenyl)azo]-2 -naphthalenesulfonic acid complex was estimated to be 3.162 L/kg whole body w.w (at 25 deg C) which does not exceed the bio concentration threshold of 2000, indicating that the chemical aluminium, 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonic acid complex is not expected to bioaccumulate in the food chain.

Additional information

Bioaccumulation: aquatic / sediment

Various predicted data for the target compound aluminium, 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonic acid complex (CAS No. 15790-07-5) and supporting weight of evidence study for its read across substance were reviewed for the bioaccumulation end point which are summarized as below:

 

In aprediction done using theBCFBAF Program(v3.01) of Estimation Programs Interface (EPI Suite, 2017) was used to predict the bioconcentration factor (BCF) of test chemical aluminium, 6 -hydroxy-5 -[(4 -sulfophenyl)azo]-2 -naphthalenesulfonic acid complex (CAS No. 15790 -07 -5). The bioconcentration factor (BCF) of aluminium, 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonic acid complex was estimated to be 3.162 L/kg whole body w.w (at 25 deg C) which does not exceed the bio concentration threshold of 2000, indicating that the chemical aluminium, 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonic acid complex is not expected to bioaccumulate in the food chain.

 

In a supporting weight of evidence study from secondary source (U. S. Environmental Protection Agency (EPA) Office of Pesticide Programs (OPP), 2005), bioaccumulation study was conducted for estimating the BCF (bioaccumulation factor) value of test chemical aluminium, 6 -hydroxy-5 -[(4 -sulfophenyl)azo]-2 -naphthalenesulfonic acid complex (CAS no. 15790 -07 -5). The estimated BCF (bioaccumulation factor) of test chemical aluminium, 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonic acid complex was determined to be 3.162 dimensionless (log BCF = 0.5), which does not exceed the bioconcentration threshold of 2000, indicating that the chemical aluminium, 6 -hydroxy-5 -[(4 -sulfophenyl) azo]-2 -naphthalenesulfonic acid complex is considered to be non-accumulative in aquatic organisms.

 

For the read across chemical calcium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]-2-naphthoate (CAS no. 5281-04-9) from authoritative database (J-CHECK, 2017) and secondary source (OECD SIDS, 1994),bioaccumulation experiment was conducted on test organism Cyprinus carpiofor 6 weeks for evaluating the bioconcentration factor (BCF value) of read across chemical calcium 3 -hydroxy-4 -[(4 -methyl-2 -sulfonatophenyl)diazenyl]-2 -naphthoate. The study was performed according to OECD Guideline 305 (Bioconcentration: Flow-through Fish Test) and other guideline "Bioaccumulation test of a chemical substance in fish or shellfish" provided in "the Notice on the Test Method Concerning New Chemical Substances", respectively at a temperature of 25°C. Cyprinus carpio was used as a test organism for the study. Test chemical nominal conc. used for the study were 0.3mg/land 0.03 mg/l, respectively. Test chemical solution was prepared in HCO-40 and Crystal sugar. Analytical method involve therecovery ratio: Fish : 79.6 %, - Limit of quantitation : Test water : 1st concentration area : 0.017 microg/mL, 2nd concentration area : 0.00 microg/mL, Fish : 0.18 microg/g.Range finding study involve theLC50(48h) >= 50.0 mg/LonRice fish (Oryzias latipes).The bioconcentration factor (BCF value) of substance calcium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]-2-naphthoateonCyprinus carpio was determined to be in the range of ≤ 0.7-1.8 L/Kg at a conc. of 0.3 mg/l and ≤ 6.9 L/Kg at a conc. of 0.03 mg/l, respectively, which does not exceed the bioconcentration threshold of 2000, indicating that the chemical calcium 3-hydroxy-4-[(4-methyl-2-sulfonatophenyl)diazenyl]-2-naphthoate is not expected to bioaccumulate in the food chain.

 

On the basis of above results for target chemicalaluminium, 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonic acid complex(from EPI suite, 2017and secondary source,  2005) and for its read across substance (from authoritative database J-CHECK and secondary source OECD SIDS), it can be concluded that the BCF value of test substance aluminium, 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonic acid complex was estimated to be 3.162 which does not exceed the bioconcentration threshold of 2000, indicating that the chemicalaluminium, 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonic acid complexis not expected to bioaccumulate in the food chain.