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EC number: 610-122-1 | CAS number: 433733-94-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26.5.2009 - 29.5.2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Samples for possible analysis were taken from all test concentrations and the control:
Frequency at t=0 h, t=24 h and t=72 h
Volume 1.5 ml - Vehicle:
- yes
- Remarks:
- M2
- Details on test solutions:
- Preparation of test solutions started with the highest test concentration of 100 mg/L. No special treatment other than careful shaking 5 min of ultrasonic treatment were applied to completely dissolve the test substance in the test medium. The lower test concentrations were prepared by subsequent dilutions in test medium. The final test solutions were all clear and colourless.
- Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- Pseudokirchneriella subcapitata, strain: NIVA CHL 1
Algae stock cultures were started by inoculating growth medium with algal cells from a pure culture on agar. The suspensions were continuously aerated and exposed to light in a climate room at a temperature of 21-24°C. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 72 h
- Test temperature:
- 22.1 - 23.1 °C
- pH:
- 8.1
- Nominal and measured concentrations:
- Analysis of the samples taken from the highest test concentration of 100 mg/I showed that the measured concentration was relatively stable and in agreement with nominal during the test period (83-99%).
Nominal test concentrations: 1, 10, 100 mg/L - Details on test conditions:
- The pH was within the limits prescribed by the protocol (6.0-9.0, preferably not varying by more than 1.5 unit). The temperature of the test medium was 23.1 °C at the start of the test. During the exposure period the temperature measured in the incubator was maintained between 22.1 and 23.1 °C.
Temperature remained within the limits prescribed by the protocol (21-24 °C, constant within
2°c). - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- biomass
- Results with reference substance (positive control):
- ErC50 = 1.8 mg/L (date of the experiment: 6 April 2009)
The EC50 for growth rate reduction (ERC50: 0-72h) was 1.8 mg/I with a 95 % confidence interval ranging from 1.4 to 2.5 mg/I. The historical ranges for grow1h rate reduction lie between 0.82 and 2.3 mg/I. Hence, the ERC50: 0-72h for the present batch corresponds with this range.
The EC50 for yield inhibition (EvC50: 0-72h) was 0.6 mg/I with a 95 % confidence interval ranging from 0.5 to 0.9 mg/I. - Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of the present study with Pseudokirchnerielfa subcapitata exposed to LDT600 C3, both the EC50 for growth rate reduction (ErC50: 0-72h) and the EC50 for yield inhibition (EyC50: 0-72h) exceeded an analytically confirmed concentration of 100 mg/I.
According to the classification criteria described in REGULATION (EC) No 1272/2008 (CLP) the product has not to be classified.
Reference
Under the conditions of the present study with Pseudokirchnerella subcapitata exposed to the test substance, both the EC50 for growth rate reduction and the EC50 for yield inhibition exceeded an analytically confirmed concentration of 100 mg/l.
Effects of the test substance on algal growth were minimal with 5.8% reduction of growth and 26% inhibition of yield at the highest test concentration of 100 mg/L.
Description of key information
Under the conditions of the present study with Pseudokirchnerielfa subcapitata exposed to LDT600 C3, both the EC50 for growth rate reduction (ErC50: 0-72h) and the EC50 for yield inhibition (EyC50: 0-72h) exceeded an analytically confirmed concentration of 100 mg/I.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 100 mg/L
- EC10 or NOEC for freshwater algae:
- 10 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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