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Diss Factsheets
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EC number: 241-620-3 | CAS number: 17636-10-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Experimental investigation, EU C.7/OECD 111, 25 °C, pH 4 and 7: hydrolytically stable; pH 9: half-life of 52.3 h, rate constant: 5.52 x 10E-4/h
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 52.3 d
- at the temperature of:
- 25 °C
Additional information
An investigation of the hydrolytic behaviour of the test substance as function of pH was carried out at pH 4, 7 and 9 in an experiment following the principles of EU Method C.7 / OECD Guideline 111 (Tarran, 2012). Hydrolysis occurs, when a substance reacts with water. The kinetics were consistent with pseudo-first order reactions, since the graphs of log concentration versus time are straight lines. The substance concentration is determined as a function of time. High Performance Liquid Chromatography (HPLC) was the analytical method of choice. The test was performed under sterile conditions and in vessels shielded from light. Sample solutions were prepared in stoppered glass flasks at a nominal concentration of 0.1 g/L for the preliminary test and 1 g/L for all other tests in the three buffer solutions. In the preliminary test, the sample solutions were maintained at 50 +/- 0.5 °C for a period of 5 days. The results showed that it was necessary to undertake further testing (Tier 2) at all pH values at various temperatures, since more than 10 % hydrolysis had occurred. Tier 2 testing was sufficient for pH 4 and 9, concluding that the test substance will be stable. At pH 7, approximately 15 % hydrolysis was recorded at 70 °C after 5 days; while 30 % hydrolysis had occurred after 5 days at 50 °C in the preliminary test before. Therefore, the Tier 1 testing was repeated. As final result, the test substance has to be considered as stable at pH 4 and 7, since the half-lives were calculated as > 1 year at 25 °C. No rate constants can be derived. The half-life at pH 9 at 25 °C will be 52.3 days with a rate constant of 5.52 x 10E-4/h. As the substance was determined to be hydrolytically stable under acidic conditions, no additional testing at pH 1.2 and 37 +/- 0.5 °C was performed (optional test under OECD 111).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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