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Environmental fate & pathways

Hydrolysis

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
17 September 1996 to 13 January 1997
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Qualifier:
according to guideline
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
GLP compliance:
yes (incl. QA statement)
Specific details on test material used for the study:
Identity: FAT 40557/A
Batch-no.: PV1
Appearance: Solid powder, red-brown
Expiration date: September, 2002
Storage conditions: At room temperature
Radiolabelling:
no
Analytical monitoring:
yes
Buffers:
pH 4.0: Ciba-Geigy Code No. P07: 0.1 mole acetic acid + 0.1 mole sodium acetate diluted to 1000 mL with water + 60.0 mL 1 N HCI.
pH 7.0: Ciba-Geigy Code No. P10: 0.041 mole disodium hydrogen phosphate+ 0.028 mole potassium dihydrogen phosphate diluted to 1000 mL with water.
pH 9.0: Ciba-Geigy Code No. P12: 0.043 mole disodium tetraborate + 0.017 mole potassium dihydrogen phosphate diluted to 1000 mL with water.
Details on test conditions:
300.0 to 330.0 mg test substance was dissolved and diluted to 100.0 mL with water. 10 mL of this solution was pipetted into a 100 mL measuring flask, which was then filled up to the mark with the respective buffer solution. The temperature and the pH are checked (pH 4, 7 and 9).
Duration:
2.4 h
Temp.:
50 °C
Initial conc. measured:
>= 0.304 - <= 0.317 g/L
Duration:
5 d
Temp.:
50 °C
Initial conc. measured:
>= 0.304 - <= 0.317 g/L
Duration:
43.2 h
pH:
4
Temp.:
40 °C
Initial conc. measured:
>= 0.303 - <= 0.324 g/L
Duration:
47.5 h
pH:
9
Temp.:
60 °C
Initial conc. measured:
>= 0.302 - <= 0.325 g/L
Duration:
92.9 h
pH:
4
Temp.:
25 °C
Initial conc. measured:
>= 0.315 - <= 0.319 g/L
Duration:
6.7 h
pH:
9
Temp.:
70 °C
Initial conc. measured:
>= 0.309 - <= 0.311 g/L
Duration:
5.9 h
pH:
9
Temp.:
80 °C
Initial conc. measured:
>= 0.302 - <= 0.328 g/L
Number of replicates:
2
Preliminary study:
After 2.4 h at 50 °C pH 4: 15.1 %; pH 7: 1. 4%; pH 9: 3.9 %
After 5 days at 50 °C pH 4: 100 %; pH 7: 4.2 %; pH 9: 65 %
At 50 °C the test substance FAT 40557/A hydrolyses less than 10 % at pH 7, no further testing at pH 7 is necessary. The hydrolysis of the test substance is examined at pH 4 and 9 .
Transformation products:
not measured
pH:
4
Temp.:
25 °C
Hydrolysis rate constant:
0 s-1
DT50:
71.3 h
Type:
(pseudo-)first order (= half-life)
pH:
4
Temp.:
40 °C
Hydrolysis rate constant:
0 s-1
DT50:
22.3 h
Type:
(pseudo-)first order (= half-life)
pH:
9
Temp.:
25 °C
Hydrolysis rate constant:
0 s-1
DT50:
2 976.4 h
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: Calculated from other temperatures
pH:
9
Temp.:
60 °C
Hydrolysis rate constant:
0 s-1
DT50:
21.9 h
Type:
(pseudo-)first order (= half-life)
pH:
9
Temp.:
70 °C
Hydrolysis rate constant:
0 s-1
DT50:
7.7 h
Type:
(pseudo-)first order (= half-life)
pH:
9
Temp.:
80 °C
Hydrolysis rate constant:
0 s-1
DT50:
2.1 h
Type:
(pseudo-)first order (= half-life)

Preliminary study:


At 50 °C the test substance FAT 40557/A hydrolyses more than 10 % at pH 4 and pH 9. For this reason, the hydrolysis is examined at pH 4 and pH 9. The test substance is stable at pH 7 at 50 °C; it has a half-life period longer than one year at 25 °C and pH 7. Test 1 and Test 3 must be carried out at pH 4 and pH 9.

Validity criteria fulfilled:
yes
Conclusions:
The test substance has a half-life period of longer than one year at 25 °C and pH 7.
Executive summary:

In a GLP-compliant hydrolysis test performed according to OECD guideline 111, the stability of the test substace was determined at pH 4, 7, and 9. In a preliminary study, it was determined that the test substance was stable at pH 7 at 50 °C with a calculated half-life period longer than one year at 25 °C and therefore no further testing was performed at pH 7. In two additional tests, it was determined that the the half-life period at 25 °C at pH 4 and 9 was 71.2 hours (3 days) and 2976.4 hours (124 days), respectively.

Description of key information

The test substance is hydrolytically stable.

Key value for chemical safety assessment

Half-life for hydrolysis:
1 yr
at the temperature of:
25 °C

Additional information

In a GLP-compliant hydrolysis test performed according to OECD guideline 111, the stability of the test substance was determined at pH 4, 7, and 9 (CG 1997). In a preliminary study, it was determined that the test substance was stable at pH 7 at 50 °C with a calculated half-life period longer than one year at 25 °C and therefore no further testing was performed at pH 7. In two additional tests, it was determined that the half-life period at 25 °C at pH 4 and 9 was 71.2 hours (3 days) and 2976.4 hours (124 days), respectively.