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Diss Factsheets
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EC number: 247-987-6 | CAS number: 26762-92-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
- Value:
- 0.62 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
- Route of original study:
- By inhalation
DNEL related information
- DNEL derivation method:
- other: Guidance on information requirements and chemical safety assessment Chapter R.8: Characterisation of dose [concentration]-response for human health ver 2, Dec. 2010
- Overall assessment factor (AF):
- 50
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 31 mg/m³
- Explanation for the modification of the dose descriptor starting point:
- local effects at the site of exposure
- AF for dose response relationship:
- 1
- Justification:
- study indicates both NOAEC and LOAEC
- AF for differences in duration of exposure:
- 2
- Justification:
- sub-chronic to chronic (based on 90-day study)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- local effect primary effect
- AF for other interspecies differences:
- 2.5
- Justification:
- identical to that used for systemic effects
- AF for intraspecies differences:
- 5
- Justification:
- factor for workers considered worst case as no species difference was seen in dermal studies with rats and mice
- AF for the quality of the whole database:
- 2
- Justification:
- NOAEC based on a study with a structural analogue
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
- DNEL extrapolated from long term DNEL
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.62 mg/m³
- Most sensitive endpoint:
- irritation (respiratory tract)
DNEL related information
- DNEL derivation method:
- other: Guidance on information requirements and chemical safety assessment Chapter R.8: Characterisation of dose [concentration]-response for human health ver 2, Dec. 2010
- Overall assessment factor (AF):
- 50
- Dose descriptor:
- NOAEC
- AF for dose response relationship:
- 1
- Justification:
- study indicates both NOAEC and LOAEC
- AF for differences in duration of exposure:
- 2
- Justification:
- sub-chronic to chronic (based on 90-day study)
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- local effect primary effect
- AF for other interspecies differences:
- 2.5
- Justification:
- identical to that used for systemic effects
- AF for intraspecies differences:
- 5
- Justification:
- factor for workers considered worst case as no species difference was seen in dermal studies with rats and mice
- AF for the quality of the whole database:
- 2
- Justification:
- NOAEC based on a study with a structural analogue
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
- Value:
- 0.15 mg/kg bw/day
- Most sensitive endpoint:
- skin irritation/corrosion
- Route of original study:
- Dermal
DNEL related information
- DNEL derivation method:
- other: Guidance on information requirements and chemical safety assessment Chapter R.8: Characterisation of dose [concentration]-response for human health ver 2, Dec. 2010
- Overall assessment factor (AF):
- 20
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 3 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- not justified, because the primary effect is a local effect
- AF for dose response relationship:
- 1
- Justification:
- 90-day study with NOAEL and LOAEL
- AF for differences in duration of exposure:
- 2
- Justification:
- sub-chronic to chronic
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- primary effect is local effect
- AF for other interspecies differences:
- 1
- Justification:
- mechanism destruction of membranes
- AF for intraspecies differences:
- 5
- Justification:
- factor for workers considered worst case as no species difference was seen in dermal studies with rats and mice
- AF for the quality of the whole database:
- 2
- Justification:
- NOAEL based on a study with a structural analogue
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- no DNEL required: short term exposure controlled by conditions for long-term
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 3 µg/cm²
- Most sensitive endpoint:
- skin irritation/corrosion
DNEL related information
- DNEL derivation method:
- other: based on NOAEL of 3 mg/kg bw (0.15% or 0.009 mg/cm2)
- Overall assessment factor (AF):
- 3
- Dose descriptor:
- other: NOAEL
- AF for dose response relationship:
- 1
- Justification:
- 90-day study with NOAEL and LOAEL
- AF for differences in duration of exposure:
- 1
- Justification:
- primary effect is local effect
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- primary effect is local effect
- AF for other interspecies differences:
- 1
- Justification:
- mechanism destruction of membranes
- AF for intraspecies differences:
- 3
- Justification:
- ecetoc factor, factor of 5 is considered high, because of nature of effect (local)
- AF for the quality of the whole database:
- 1
- Justification:
- NOAEL based on a study with a structural analogue, but with similar mechanism of action
- AF for remaining uncertainties:
- 1
Acute/short term exposure
- Hazard assessment conclusion:
- high hazard (no threshold derived)
- Value:
- 125 µg/cm²
- Most sensitive endpoint:
- skin irritation/corrosion
DNEL related information
- DNEL derivation method:
- other: based on primary irritation test in maximisation study (CIT, 1994)
- Overall assessment factor (AF):
- 10
- Dose descriptor starting point:
- other: non-irritant concentration of 1%
- AF for dose response relationship:
- 2
- Justification:
- no complete report on irritation; differences between two studies
- AF for interspecies differences (allometric scaling):
- 1
- Justification:
- primary effect is local effect
- AF for other interspecies differences:
- 1
- Justification:
- mechanism destruction of membranes
- AF for intraspecies differences:
- 5
- Justification:
- factor for workers considered worst case as no species difference was seen in dermal studies with rats and mice
- AF for the quality of the whole database:
- 1
- AF for remaining uncertainties:
- 1
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- high hazard (no threshold derived)
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
No DNELs were calculated for the general population as the test substance will be used only in industrial settings.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.