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EC number: 231-600-2 | CAS number: 7647-17-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Remarks:
- mouse LLNA ASSAY
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2012-02-01 to 2012-02-09
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP and guideline compliant. An experimental study was performed with a structural analogous read-across substance. Please refer to IUCLID section 13 for read-across justification.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Version / remarks:
- , adopted 2012
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.42 (Skin Sensitisation: Local Lymph Node Assay)
- Version / remarks:
- , adopted 2008
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2600 (Skin Sensitisation)
- Version / remarks:
- , adopted 2003
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Caesium nitrate
- EC Number:
- 232-146-8
- EC Name:
- Caesium nitrate
- Cas Number:
- 7789-18-6
- Molecular formula:
- Cs.HNO3
- IUPAC Name:
- cesium nitrate
- Test material form:
- solid: crystalline
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: TOXI-COOP ZRT. H-1103, Budapest, Cserkesz u. 90.
- Age at study initiation: young adult mice, 9-10 weeks (at start of the experiment)
- Weight at study initiation: 16.8 - 21.5 g
- Housing: grouped caging (5 animals/cage)in type II. polypropylene/polycarbonate cages
- Diet: Animals received ssniff® SM R/M-Z+H complete diet for rats and mice produced by ssniff Spezialdiäten GmbH, D-59494 Soest, Germany, ad libitum
- Water: tap water for human supply, ad libitum
- Acclimation period: 7 days (pre-test) and 21 days (main study)
ENVIRONMENTAL CONDITIONS
- Temperature: :22 ± 3 °C
- Humidity: 30 – 70 %
- Photoperiod: 12 hours daily, from 6.00 a.m. to 6.00 p.m.
Results and discussion
- Positive control results:
- The positive control group animals were treated with 25 % (w/v) Hexyl cinnamic aldehyde (HCA) solution concurrent to the test item treated groups. No confounding effects of irritation or systemic toxicity were observed in the positive control group. Significant lymphoproliferative response (SI 3) was noted for HCA with stimulation index value of 11.82. The result of the positive control item demonstrated the appropriate performance of the test in accordance with the Guidelines and confirmed sensitivity and validity of the assay.
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: The Stimulation index values per treatment group were as follows: negative control: 1.0 SI positive control: 11.82 SI Test item: 25 %: 0.91 SI 10 %: 0.72 SI 5 %: 0.97 SI 2.5 %: 1.05 SI
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: The mean DPM values per treatment group were as follows: negative control: 818.4.0 DPM positive control: 18398.6 DPM Test item: 25 %: 743.0 DPM 10 %: 588.0 DPM 5 %: 795.0 DPM 2.5 %: 858.6 DPM
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- No study on skin sensitisation with cesium chloride is available. Consequently, read-across with cesium nitrate was performed. Cesium nitrate tested at 25 %, 10 %, 5% and 2.5 % as a solution in 1 % Pluronic was shown to have no sensitisation potential. Accordingly, cesium chloride is considered to have no sensitisation potential.
- Executive summary:
No study on skin sensitisation with cesium chloride is available. Consequently, read-across with cesium nitrate was performed.
The aim of this study was to determine the skin sensitisation potential of cesium nitrate in the Local Lymph Node Assay (LLNA) according to the OECD Guideline 429 and EU Method B.42. The individual approach was used in this test whereby the lymph nodes of each animal were evaluated individually (in comparison to a pooled test group approach). The maximum attainable test item concentration, resulting in a homogenous formulation in an appropriate vehicle, was examined.
A preliminary solubility test was performed to select a suitable vehicle. The maximum attainable test concentration based on solubility was 25 % (w/v) in aqueous 1 % Pluronic. No higher test concentration was available in this test.
Based on results of a preliminary irritation/toxicity test 25 % was selected as the highest test concentration in the main test.
In the main test, 35 female CBA/Ca mice were allocated to seven groups of five animals each:
-four groups received cesium nitrate at 25 %, 10 %, 5 % or 2.5 %,
-the negative control group received the vehicle (1 % Pluronic) only,
-the positive control group received 25 % alpha-Hexylcinnamaldehyde
-the negative control group for the positive control group received Acetone: Olive oil 4:1 mixture (v/v/) (AOO) only.
Each substance was applied on the external surface of each ear (25 µL/ear) of the animals for three consecutive days (Day 1, 2 and 3).
There was no treatment on Days 4, 5 and 6. On Day 6, the cell proliferation in the local lymph nodes was measured by determining incorporation of tritiated methyl thymidine (3HTdR) and the obtained values were used to calculate stimulation indices (SI). No mortality was observed during the test. No local effects at the application sites (ears) were observed in any treatment group. Larger lymph nodes than the control were observed in the positive control group only. No statistically significant lymphoproliferation was observed in any group treated with the test item. The obtained SI values for the test item were 0.91, 0.72, 0.97 and 1.05 at concentrations of 25 %, 10 %, 5 % and 2.5 %, respectively. No dose-related response was observed. The positive control item induced the appropriate stimulation (SI = 11.82), thus confirming the validity of the assay. Since the mean SI value was below 3 at the maximum attainable test concentration of 25 % and at concentrations of 10 %, 5 % and 2.5 % and no dose-related response was observed, the test item was considered to be a non-sensitiser in the LLNA. Accordingly, cesium chloride is considered to have no sensitisation potential.
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