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EC number: 692-448-4 | CAS number: 170621-28-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Version / remarks:
- (adopted July 1997)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.12 (Mutagenicity - In Vivo Mammalian Erythrocyte Micronucleus Test)
- Deviations:
- no
- GLP compliance:
- yes
- Type of assay:
- mammalian erythrocyte micronucleus test
Test material
- Reference substance name:
- divanadium(5+) dialuminium(3+) magnesium(2+) nonaoxidandiide
- EC Number:
- 692-448-4
- Cas Number:
- 170621-28-0
- Molecular formula:
- Mg2xAl2xVyOz
- IUPAC Name:
- divanadium(5+) dialuminium(3+) magnesium(2+) nonaoxidandiide
- Test material form:
- solid: particulate/powder
- Details on test material:
- light yellow
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Details on species / strain selection:
- A total of 36 male and 8 female Hsd:ICR(CD-1) mice were ordered and
supplied by Charles River Italy S.p.A., Calco (Lecco), Italy. All animals were
received in good health conditions. They were 5 to 6 weeks old at the time
of treatment. Females were only used for the preliminary toxicity test that
was carried out in order to select the dose levels to be used for the Main Assay. - Sex:
- male
Results and discussion
Test results
- Key result
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- no effects
- Vehicle controls validity:
- valid
- Negative controls validity:
- not examined
- Positive controls validity:
- valid
- Additional information on results:
- RESULTS OF RANGE-FINDING STUDY
- Dose range: 1000 and 2000 mg/kg bw were tested
- Clinical signs of toxicity in test animals: all animals survived, no abnormalities detected
- Evidence of cytotoxicity in tissue analyzed: no evidence of bone marrow toxicity
- Harvest times: 24 hours after treatment
RESULTS OF DEFINITIVE STUDY
- Induction of micronuclei (for Micronucleus assay): no
- Ratio of PCE/NCE (for Micronucleus assay):
- Appropriateness of dose levels and route:
- Statistical evaluation:
Any other information on results incl. tables
Table 1: Summary
Treatment |
Dose level mg/kg bw/day |
Incidence of micronucleated PCEs |
PCEs/(PCEs+NCEs) % over the mean control value |
|||
|
|
mean |
SE |
Range |
|
|
|
|
|
|
min |
max |
|
Vehicle |
0 |
1.5 |
0.2 |
1.0 |
2.0 |
100 |
Test item |
500 |
1.8 |
0.4 |
1.0 |
3.0 |
117 |
Test item |
1000 |
0.8 |
0.2 |
0.0 |
1.0 |
100 |
Test item |
2000 |
1.4 |
0.3 |
0.5 |
2.5 |
105 |
Mitomycin C |
3.00 |
10.8*** |
1.6 |
6.0 |
16.0 |
94 |
PCE = polychromatic erythrocytes NCE = normochromatic erythrocytes *** = incidence significantly greater than control value at p < 0.001 |
Applicant's summary and conclusion
- Conclusions:
- It is concluded that, under the reported experimental conditions, aluminium magnesium vanadium oxide, administered by oral gavage, does not induce cytogenetic damage and/or disruption of the mitotic apparatus in mouse bone marrow, as measured by the induction of micronuclei in polychromatic erythrocytes.
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