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EC number: 266-358-7 | CAS number: 66423-13-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to birds
Administrative data
- Endpoint:
- short-term toxicity to birds: acute oral toxicity test
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reliable source.
Data source
Reference
- Reference Type:
- other: unpublished study
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 71-1 (Avian Acute Oral Toxicity Test)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- 66423-09-4
- Cas Number:
- 66423-09-4
- IUPAC Name:
- 66423-09-4
- Reference substance name:
- Mecoprop-P dimethylamine salt
- IUPAC Name:
- Mecoprop-P dimethylamine salt
- Reference substance name:
- MCPP-P DMA
- IUPAC Name:
- MCPP-P DMA
- Reference substance name:
- R-(+)-2-(4-chloro-2-methylphenoxy)-propionic acid, dimethylamine salt
- IUPAC Name:
- R-(+)-2-(4-chloro-2-methylphenoxy)-propionic acid, dimethylamine salt
- Details on test material:
- Mecoprop-P dimethylamine salt (MCPP-P DMA): 65.62 %, eqivalent to 54.23 % Mecoprop-P acid (MCPP-P acid)
Constituent 1
Constituent 2
Constituent 3
Constituent 4
- Dose method:
- gavage
Test organisms
- Test organisms (species):
- Colinus virginianus
- Details on test organisms:
- males/females, 1/1; 22 weeks old
Study design
- Limit test:
- no
- Total exposure duration (if not single dose):
- 14 d
Results and discussion
Effect levels
- Duration (if not single dose):
- 14 d
- Dose descriptor:
- LD50
- Effect level:
- 497 mg/kg bw
- Conc. / dose based on:
- test mat.
- Basis for effect:
- mortality
Any other information on results incl. tables
Chalky diarrhea was noted in all groups, however, the animals recovered after day 2 at 191 and 318 mg/kg bw dose level. Lethargy and hypersalivation were observed at the highest dose level. Mortality occurred from 529 mg/kg bw and all birds died at the two highest dose levels. LD50 was determined as 602 mg MCPP-P DMA/kg bw eqivalent to 497 mg MCPP-P acid/kg bw.
The body weight was reduced at 529 mg/kg bw concurrent with reduced feed consumption. Gross pathological findings that could be related to the test substance were intestinal hemorrhages and fluid filled crop in dead animals. NOEL was 263 mg MCPP-P acid/kg bw based on body weight, but including the observstion of transient diarrhea it would be < 158 mg MCPP-P acid/kg bw.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Remarks:
- expected to be valid source
- Conclusions:
- For Mecoprop-P acid (MCPP-P acid), the hydrolysis product of Mecoprop-P n-octyl ester, a 14d-LD50 of 497 mg/kg bw was determined in a oral single-dose study on Bobwhite quail.
- Executive summary:
Mecoprop-P n-octyl ester hydrolyses rapidly in natural water. Therefore, the hydrolysis product Mecoprop-P acid (MCPP-P acid) was used for further assessment of Mecoprop-P n-octyl ester with respect to toxicity on birds.
In an oral single-dose test, according to the EPA OPP 71 -1, for Mecoprop-P acid (MCPP-P acid) a 14d-LD50 of > 497 mg/kg bw was obseved on Bobwhite quail.
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