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Diss Factsheets
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EC number: 947-945-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 260.9 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- K2 level publication
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Based on the various studies available with Klimish rating 2 for the read across substances for CAS: 37330-39-5 based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. This data is combined with the prediction done using the QSAR toolbox for the target chemical based on similar category approach, the results is summarized as follows:
Sr. No | End point | Value | Species | Route | Effects | Remarks |
1. | NOAEL | 261 mg/kg bw/day | Rat | Oral | No adverse effects observed. | Predicted data QSAR |
2. | LOAEL | 125 mg/kg bw/day | Rat | Oral | some evidence of maternal toxiclty was observed | Study report RA-27193-86-8 |
3. | NOAEL
LOAEL
NOAEL
LOAEL | 25 mg/kg bw/day.
50 mg/kg bw/day.
50 mg/kg bw/day. 100 mg/kg bw/day | Mouse | Oral | -No effects reproductive organ weight, sperm motility and count,spermatozoa morphology.. -significant increase in the mean weight of caudae epididymis and prostate.. -no change in the dead implants per pregnant female mice. -decrease the rate of pregnancy and cause embryonic losses implantation. |
Publication data |
Short description of key information:
The NOAEL (no adverse effect level) of Cardanol in rats was observed at a dose level of 260.90mg/kg bw/day.
Justification for selection of Effect on fertility via oral route:
The NOAEL (no adverse effect level) of Cardanol in rats was observed at a dose level of 260.90mg/kg bw/day.
Effects on developmental toxicity
Description of key information
The NOAEL (no adverse effect level) of Cardanol in rats was observed at a dose level of 337.65mg/kg bw/day.
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 337.65 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
- Quality of whole database:
- K2 level data predicted using QSAR toolbox.
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Based on the various studies available with Klimish rating 2 for the read across substances for CAS: 37330-39-5 based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. This data is combined with the prediction done using the QSAR toolbox for the target chemical based on similar category approach, the results is summarized as follows
Sr. No | End point | Value | Species | Route | Effects | Remarks |
1. | NOAEL (Developmental toxicity) | 337.666656494 mg/kg bw/day | Rat | Oral | No adverse effects observed. | Predicted data QSAR |
2. | NOAEL(Fetotoxicity) | 500 mg/kg bw/day | Rat | Oral | There was no evidence of fetotoxicity | Study report RA-27193-86-8 |
3. | NOAEL-Maternal toxicity-Female LOAEL- Maternal toxicity -Female | 50 mg/kg bw/day.
100 mg/kg bw/day. | Mouse | Oral | -No change in the dead implants per pregnant female mice. -decrease the rate of pregnancy and cause embryonic losses implantation. | Publication RA 8007-24-7 |
Based on the studies summarized in the above table with various routes it can be observed that NOAEL values varies from 50 - 500 mg/Kg bw/ d. The no effects observed/effects observed on the these doses was listed as follows
-Overall effects-no adverse effects observed on body weight,food consumption etc.
-No evidence of fetotoxicity observed.
-decrease the rate of pregnancy and cause embryonic losses implantation.
Thus based on above discussion it can be concluded that substance CAS: 37330-39-5 is expected to show the similar toxicological effect based on the effects observed on the other category members. Since the no effective dose values (NOAEL) of target and readacross is in the range50 - 500 mg/Kg bw/ dthus based on this value it can be concluded that substance CAS: 37330-39-5 is considered to be not toxic to maternal toxicity as well as developmental effects below the above mentioned doses.The LOAEL value of readacross is a conservative value falling within the range. Moreover there are no known evidence of adverse effect on reproduction to Human of CAS: 37330-39-5 as well as estrogen receptor binding affinity does not indicates any mechanistic trigger based on absence of complex noncyclic structure that would raise concern of developmental toxicity.
Justification for selection of Effect on developmental toxicity: via oral route:
The NOAEL (no advesrse effect level) of Cardanol in rats was observed at a dose level of 337.65mg/kg bw/day.
Justification for classification or non-classification
The chemical Cardanol does not exhibit toxicity to the reproductive system as well as developmental toxicity within the doses mentioned in the various end points.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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