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EC number: 613-005-3 | CAS number: 62298-52-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Dec 1995 - Jan 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to OECD guideline under GLP
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- Principles of method if other than guideline:
- Not relevant
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-Methoxy-18-methyl-8,14-seco-1,3,5(10),9(11)-estratetraene-14,17-dione
- EC Number:
- 613-005-3
- Cas Number:
- 62298-52-6
- Molecular formula:
- C20H24O3
- IUPAC Name:
- 3-Methoxy-18-methyl-8,14-seco-1,3,5(10),9(11)-estratetraene-14,17-dione
- Details on test material:
- - Name of test material (as cited in study report): 17-Keto-Ethyl-Seco-Verbindung
- Analytical purity: 98.8
- Lot/batch No.: 10037206
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 12 mg/L
- Based on:
- DOC
Results and discussion
% Degradation
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 10
- Sampling time:
- 28 d
- Details on results:
- The reference compound sodium acetate was degraded to 100% on day 29. The time required for 60% biodegradation of the reference compoundwasless than 8 days. In the toxicity control, the reference compound (sodium acetate) plus the test compound ZK 46073 was degraded to 42% on day 29.
Any other information on results incl. tables
Table 1: Biological degradation (cumulative) in percent of ZK 46073 (corrected for blank C02 production)
Test | Nominal | Day of sampling | ||||||||||
compound | concentration of carbon | 1 | 3 | 6 | 8 | 10 | 14 | 17 | 21 | 24 | 28 | 29 |
ZK 46073 | 12 mg/L | 1 | 1 | 1 | 1 | 3 | 3 | 7 | 8 | 9 | 10 | 10 |
Sodium acetate (reference) | 10 mg/L | 1 | 25 | 54 | 66 | 72 | 77 | 87 | 90 | 94 | 99 | 100 |
ZK 46073 + sodium acetate (toxicity control) | 12 mg/L + 10 mg/L | 1 | 10 | 19 | 25 | 30 | 34 | 37 | 37 | 38 | 39 | 42 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- inherently biodegradable
- Conclusions:
- In accordance with the OECD guideline, the test compound ZK 46073 is not readily
biodegradable under the conditions of the test. The substance was not toxic to the microbes of
activated sludge. - Executive summary:
The purpose of this study was to determine the ready biodegradability of 17 -Keto-Ethyl-Seco-Verbindung (ZK 46073). The study was conducted in agreement with the test guideline OECD guideline for testing of chemicals, Ready biodegradability: C02-evolution test, no. 301 B.
The test substance was incubated in an aqueous solution including nutrients with microorganisms from a municipal sewage treatment plant for 28 days (start of treatment = day 0). The nutrient solutions were made up of phosphates, magnesium sulphate, iron chloride, ammonium chloride and calcium chloride. The test substance was incubated in a concentration of 12 mg carbon/L in duplicate. Additionally, one set with the reference substance (sodium acetate) was incubated in a concentration of 10 mg carbon/L and tested according to the same procedure, in order to verify the viability and activity of the degrading micro-organisms. Furthermore, a blank control was tested in duplicate without any test or reference substance. One further set was incubated with sodium acetate as 10 mg carbon/L (reference substance) plus ZK 46073 as 12 mg carbon/L representing a toxicity control. The biological degradation of the test and reference substances was evaluated by measurement of the carbon dioxide (C02) produced during the test period. CO2 production was determined on days 1, 3, 6, 8, 10, 14, 17, 21, 24, 28 and 29 and calculated as the percentage of total CO2 that the test material could theoretically have produced, based on carbon content. The blank CO2 production was subtracted for correction.
The test compound ZK 46073 was degraded to 10% at the end of the test. The reference compound sodium acetate was degraded to 100% on day 29. The time required tor 60% biodegradation of the reference compound was less than 8 days. In the toxicity contral, the reference compound (sodium acetate) plus the test compound was degraded to 42% on day 29. The degradation in the toxicity control was slightly lower than the degradation of the respective individual substances. The lower degradation noted in the toxicity control compared to the reference substance is considered to be a laboratory-specific phenomenon and not due to toxic effects.
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