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EC number: 412-280-5 | CAS number: 2511-00-4 POIRENATE
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 14 to 16 January 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to the OECD Guideline and it is GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Ethyl 2-cyclohexylpropionate
- EC Number:
- 412-280-5
- EC Name:
- Ethyl 2-cyclohexylpropionate
- Cas Number:
- 2511-00-4
- Molecular formula:
- C11H20O2
- IUPAC Name:
- ethyl 2-cyclohexylpropanoate
- Details on test material:
- - Physical state: clear liquid
- Stability under test conditions: verified by chemical analysis. Water samples were taken from the control and all test concentrations at 0 hours and from the control and all relevant test concentrations at 48 hours and sent to HRC Departmenet of anlytical Chemistry for analysis.
- Storage condition of test material: in darkness at 4ºC
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna (Straus)
- Source: Laboratory culture originating from a strain supplied by IRChA, France
Study design
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 150-200 mg/L as CaCO3
- Test temperature:
- 21ºC
- pH:
- 7.6
- Dissolved oxygen:
- 8.6 mgO2/L
- Nominal and measured concentrations:
- Nominal test concentrations: 0.10, 0.18, 0.32, 0.56, 1.0, 1.8, 3.2, 5.6 and 10 mg/L.
Relevant measured test concentrations: 0.30, 0.94, 1.6, 2.9 and 5.9 mg/l. - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass jars each containing 200 ml test solution. The jars covered with aluminium foil with minimim headspace.
- Experimental design: 9 test concentrations plus 1 control, each in duplicate. 20 animals per test concnetrations.
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Details on results:
- All calculations are based on mean measured concentrations. Values obtained ranged from 64-75% of nominal (mean value 70%) at 0 hours (fresh media) and from 35 to 43% of nominal (mean value 39% at 48 hours (expired media). Despite the use of covered vessels with minimum headspace, stable concentrations could not be maintained due to the volatility of the test substance. The low values measured at 0 hours suggest that much of the maintained due to the volatility of the test substance. The low values measured at 0 hours suggest that much of the losses occur during sampling and handling of the test media.
Data for the 1 mg/l treatment have not been included in these calculations due to a suspected sampling/analytical error at 48 hours. This is not considered to have any significant effect on the overall results of the tes, however, since there are sufficient data remaining to define adequately the EC50 value (as indicated by the narrow 95% confidence limits) and the "no effect" levels.
Any other information on results incl. tables
Table 1
Cumulative immobilisation data for Daphnia magna exposed for 48 hours to the test substance
Nominal concentration mg/l | Measured concentration mg/l | Cumulative immobilised Daphnia magna (initial population:20) | |||||||
24 hours | 48 hours | ||||||||
R1 | R2 | Total | % | R1 | R2 | Total | % | ||
Control | Control | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5 |
0,1 | - | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 5 |
0,18 | - | 1 | 0 | 1 | 5 | 1 | 0 | 1 | 5 |
0,32 | - | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5 |
0,56 | 0,3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
1 | - | 1 | 0 | 1 | 5 | 3 | 3 | 6 | 30 |
1,8 | 0,94 | 0 | 0 | 0 | 0 | 4 | 3 | 7 | 35 |
3,2 | 1,6 | 0 | 1 | 1 | 5 | 3 | 6 | 9 | 45 |
5,6 | 2,9 | 2 | 4 | 6 | 30 | 9 | 10 | 19 | 95 |
10 | 5,9 | 3 | 4 | 7 | 35 | 10 | 10 | 20 | 100 |
R1 Replicate 1
R2 Replicate 2
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- At 48 hours, the EC50 is 1.1 mg/l and at 0.30 mg/l there is no effect level.
- Executive summary:
The test substance was performed to obtain the Acute toxicity in Daphnia Magna 48h according to the OECD Guideline 202. All concentrations are based on mean measured concentrations. Values obtained ranged from 64 to 75% of nominal (mean value 70%) at 0 hours (fresh media) and from 35 to 43% of nominal (mean value 39%) at 48 hours (expired media).
Data for the 1 nmg/l treatment were not included in these calculation due to a suspected sampling/analytical error at 48 hours.
At 48 hours, the EC50 is 1.1 mg/l and at 0.30 mg/l there is no effect level.
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