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EC number: 247-820-7 | CAS number: 26576-46-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2008-12-18 to 2009-07-17 (experimental: 2009-02-10 to 2009-02-13)
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to current OECD-Guidelines and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Version / remarks:
- 2006
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxobutyramide
- EC Number:
- 247-820-7
- EC Name:
- N-(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-3-oxobutyramide
- Cas Number:
- 26576-46-5
- Molecular formula:
- C11H11N3O3
- IUPAC Name:
- 3-oxo-N-(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)butanamide
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
Test solutions
- Vehicle:
- no
- Details on test solutions:
- Stock solution: 200 mg/L, freshly prepared with dilution water
Dispersion treatment: Ultrasound, 30 min at 40°C
Test concentration: A limit concentration of 100 mg/L was tested.
Test organisms
- Test organisms (species):
- Desmodesmus subspicatus (previous name: Scenedesmus subspicatus)
- Details on test organisms:
- Origin: Sammlung von Algenkulturen (SAG), Pflanzenphysiologisches Institut der Universität Göttingen, Nikolausberger Weg 18, D-37073 Göttingen
Cultivation: Fresh stocks were prepared every month on Z-Agar. Light intensity amounted 35-70 µE m^(-2) s^(-1) for 24 hrs per day.
Culture medium: Nutrient medium Z according to Lüttge et al.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 72 h
Test conditions
- Hardness:
- 0.24 mmol Ca+Mg / L
- Test temperature:
- Nominal range: 21 - 24 °C, controlled at +/- 2 °C
- pH:
- 8.1 +/- 0.2
- Nominal and measured concentrations:
- Nominal concentration Measured concentration
Test start Test End
Test item (mg/L) Main comp. (mg/L) Conc. (mg/L) RR (%) Conc. (mg/L) RR (%)
100 99.5 99.5 100 80.8 81
RR = Recovery rate related to the concentration of the main component - Details on test conditions:
- TEST SYSTEM
- Test vessel: Sterile Erlenmeyer flasks, volume 250 ml sealed with cotton wool plugs
- Six replicates per limit concentration and control
- Test volume: 100 ml
- Agitation: Test containers were placed on a rotary shaker and oscillated at approximately 70 rpm.
- Light intensity: 60-120 µE m^(-2) s^(-1)
- Light regime: 24 h/d light - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate p.a. (Sigma), CAS 7778-50-9, Purity: 99.5%
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: Yield inhibition
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Remarks on result:
- other: Rate-related inhibition
- Results with reference substance (positive control):
- EC50: 0.69 mg/L (Rate-related inhibition)
EC50: 0.31 mg/L (Yield inhibition)
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- No inhibiting effects on specific growth rate and yield were found in the limit concentration of 100 mg/l. The EC50-values for specific growth rate inhibition and inhibition of yield after 72 h were > 100 mg/L.
- Executive summary:
Due to the result of this study the test item is not subject for classification concerning the Algae toxicity
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