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EC number: 414-490-2 | CAS number: 154212-59-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Mar 17 - Jun 14, 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted according to OECD and in accordance with GLP. The study material is well characterize
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Version / remarks:
- 92/69/EEC
- GLP compliance:
- yes
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- -
- EC Number:
- 414-490-2
- EC Name:
- -
- Cas Number:
- 154212-59-6
- Molecular formula:
- C11H9ClN2O5S
- IUPAC Name:
- 4-nitrophenyl (1,3-thiazol-5-yl)methyl carbonate hydrochloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl:CD(SD)BR
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River, Portage, MI
- Age at study initiation: 5 - 6 weeks
- Weight at study initiation: 114 to 145g
- Fasting period before study: Overnight
- Housing: Individual stainless steel ventilated hanging cages
- Diet: Certified Rodent Chow® ad libitum
- Water: tap water ad libitum
- Acclimation period: 6 days before study
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 71 - 72
- Humidity (%): ambient
- Photoperiod (hrs dark / hrs light):12hr daily light cycle
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- other: 0.2 % hydroxypropylmethyl cellulose (HPMC)
- Details on oral exposure:
- Using all available information on the toxicity of the test material, 2000 mg/kg was chosen as single dose.
dose volume: 10 ml/kg - Doses:
- dose level: 2000 mg/kg
- No. of animals per sex per dose:
- 5 females/males per dose
- Control animals:
- no
- Details on study design:
- 5 rats/sex were administered Abbott-87439 hydrochloride orally one time.
The day of treatment was designated Day 0.
All animals were observed frequently on the day of treatment and daily for at least 13 days after treatment for a total of 14 days. Daily observations included signs of toxicity in addition to lethality.
Animals were weighed on a weekly basis.
2 weeks after treatment all surviving rats were euthanized and necropsied.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There were 2 deaths. 1 female on day 5 and 1 female on day 6
- Clinical signs:
- other: Signs of systemic toxicity noted: Decreased activity- males; 1 on day 9, Females; 1 on day 2, 2 on day 4, 1 on day 5 and 1 on day8 Squinting: 1 female on day 1 and 1 on day 5. Dyspnea: 1 female on day 2, 1 on day 4 and 1 on day 5.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral LD50 value of the test material in male and female rats was determined to be greater than the limit dose administered to animals in this study, 2g/kg.bodyweight.
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