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Diss Factsheets
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EC number: 932-286-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 305 (Bioconcentration: Flow-through Fish Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2,2,4,6,6-pentamethylheptane-4-thiol
- EC Number:
- 296-714-7
- EC Name:
- 2,2,4,6,6-pentamethylheptane-4-thiol
- Cas Number:
- 93002-38-1
- Molecular formula:
- C12H26S
- IUPAC Name:
- 2,2,4,6,6-pentamethylheptane-4-thiol
- Details on test material:
- - Name of test material (as cited in study report): tert.-Dodecylmercaptan
- CAS-No as cited in study report: 25103-58-6 (tert. dodecanethiol), but the test material was material as defined in section 1 (CAS 93002-38-1). Therefore the new CAS number 93002-38 was assigned
- Analytical purity: not specified
- Impurities (identity and concentrations): not specified
- Source: Lanxess Deutschland GmbH (Elatomers, remark: Bayer Variante)
- Batch No.: RL71102100
Constituent 1
Sampling and analysis
- Details on sampling:
- - On day ten of the uptake phase, 4 fish for the control and 4 fish each for the test item concentrations were taken from the tanks for analytical purposes.
- After an exposure phase of 10 days the uptake phase ended. Fish were then fed with died free from the test item and reference compound and the depuration phase started. During the depuration phase fish samples for each test item concentration and control were taken on day 2, 6, 8, 11, 16, 18 and 25 after the beginning of the depuration phase. Additionally tissue specific analysis was carried out on day 2 after the beginning of the depuration phase for each test item concentration.
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- - Source: Aqua KlöGer (Germany)
- date of birth: April/May 2007
- date supplied: 2007-09-18
- Mortalities during acclimitation period: < 5%
- Medication: none
- Mean standard length and mean wet weight (sample from keeping tanks at the beginning of the study):
4.2 cm (S.D. = 0.19 cm)
885.8 mg (S.D. = 144.3 mg)
Study design
- Route of exposure:
- feed
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 10 d
- Total depuration duration:
- 25 d
Test conditions
- Test temperature:
- 20-25 °C (+/- 2°C)
- Details on test conditions:
- RANGE-FINDING:
An acute toxicity test had shown that the test item was not toxic to Danio rerio in a saturated solution of TDM (nominally: 10.7 g/L with a water solubility of 0.25 mg/L). Based on this information and the recommendations of the guidelines 100 µg/g and 1000 µg/g were selected as test concentrations for the fish dietary study.
- Photoperiod: 16h light:8h dark - Nominal and measured concentrations:
- 100 µg/g and 1000 µg/g
- Reference substance (positive control):
- yes
- Remarks:
- Hexachlorobenzene
Results and discussion
Lipid contentopen allclose all
- Lipid content:
- 14.9 %
- Time point:
- start of exposure
- Remarks on result:
- other: arith. mean value (fish taken from stock population)
- Lipid content:
- 8.8 %
- Time point:
- end of exposure
- Remarks on result:
- other: arith. mean value (control)
- Lipid content:
- 15.8 %
- Time point:
- end of exposure
- Remarks on result:
- other: arith. mean value (treatment: 1000µg/g)
Bioaccumulation factoropen allclose all
- Type:
- BMF
- Value:
- 0.01 dimensionless
- Remarks on result:
- other: Conc.in environment / dose:1000 µg/g
- Type:
- BCF
- Value:
- 1 615 dimensionless
- Remarks on result:
- other: range: 1489-1742
- Remarks:
- Conc.in environment / dose:1000 µg/g
Any other information on results incl. tables
The dietary biomagnification factor (BMF) is calculated as:
BMF = I·a· kdepuration -1
a: chemical uptake efficiency
From the data, correcting for fish growth during the test, a BMF of 0.01 was determined for the test item concentration 1000 µg/g. After 8 days of depuration (i.e. feeding unspiked food), no TDM could be determined any more.
At a concentration of 100 µg/g the bioaccumulation was too low to allow quantification.
The growth-corrected half-life is calculated as:
T1/2 = 0.693·Kdepuration-1
The calculated half life of the test item from the above data was 2.19 days.
Additionally, the average BCF was calculated by the following equation:
BCF = (Ku * T1/2) / 0.693 and
Ku = (520±40)·W-0.32 ± 0.03
Where:
Ku = the uptake rate constant (L/kg/d)
T1/2 = growth corrected half-life from dietary bioaccumulation test (days)
W = fish weight (grams wet weight) at the end of uptake/start of depuration
From the BMF data, a BCF of 1615 (1489-1742) was calculated.
The observed BMF was 0.01 and the calculated BCF is below the PBT-criterion (BCF 2000) and clearly below the vPvB-criterion (BCF 5000). Together with the short half-life these data indicate that TDM (tert.-Dodecylmercaptan) is not PBT (persistent, bioaccumulative and toxic) and not vPvB (very persistent and very bioaccumulative).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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