Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 253-057-0 | CAS number: 36483-57-5
Endpoint summary
Administrative data
Description of key information
Acute Oral toxicity study to rats
Acute dermal toxicity study to rats
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Acute oral toxicity in rats: Mortality was observed in 1 out of 3 female rats in two separate observations following oral administration of FR-513 at 2000 mg/kg. Lethargy, restless behavior, hunched posture, ventro-lateral recumbency, flat gait, uncoordinated movements, labored respiration, piloerection, salivation, ptosis, squeaking, and/or hypothermia were noted among animals between days 1 and 3. No abnormalities were found and body weight gain was considered to be normal. The oral LD50 of the test material is judged to be greater than 2000 mg/kg in female rats.
Acute dermal toxicity to rats : No mortality observed. Lethargy, flat posture, hunched posture, piloerection, ptosis, red urine, chromodacryorrhoea and/or shallow respiration were noted among the animals. The animals had recovered from the symptoms by day 5. General or maculate erythema, necrosis, scales, scars and/or scabs were seen in the treated skin-area of the animals during the observation period. No abnormalities occurred and body weight gain was considered to be normal. The dermal LD50 value FR-513 in Wistar rats was established to exceed 2000 mg/kg body weight.
Acute inhalation toxicity: FR-513 is not expected to be available through the inhalation route, since the substance is a solid, in a flakes form (not powder), with a very low estimated vapour pressure.
Justification for classification or non-classification
Based on the high LD50 values for the oral and dermal exposure, together with the unlikelyhood for inhalation exposure of the substance, FR-513 does not need to be classified for acute toxicity under the EEC criteria for classification and labelling requirements for Dangerous Substances and Preparations (67/548/EEC) and the CLP Regulation (EC No 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
