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Diss Factsheets
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EC number: 406-250-0 | CAS number: 72619-32-0 HALOXYFOP R-(+)-ME HERBICIDAL CHEMICAL
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Phototransformation in water
Administrative data
Link to relevant study record(s)
- Endpoint:
- phototransformation in water
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Study type:
- direct photolysis
- Qualifier:
- according to guideline
- Guideline:
- EPA Guideline Subdivision N 161-2 (Photodegradation Studies in Water)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: Japan MAFF 9 Nohsan 5089
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- The report represents data generated after the effective date of GLP
- Specific details on test material used for the study:
- Pyridine label:
Specific activity: 28.1 mCi/mmol
Average purity: 98.2%
UL phenyl label:
Specific activity: 18.3 mCi/mmol
Average purity: 97.8% - Radiolabelling:
- yes
- Analytical method:
- high-performance liquid chromatography
- Light source:
- Xenon lamp
- Duration:
- 9 d
- Temp.:
- 20 °C
- Initial conc. measured:
- 2 other: µg/mL
- Duration:
- 16 d
- Temp.:
- 20 °C
- Initial conc. measured:
- 2 other: µg/mL
- Reference substance:
- yes
- Dark controls:
- yes
- Quantum yield (for direct photolysis):
- 0.004
- Key result
- DT50:
- 20 d
- Test condition:
- pH 5 buffer at 40° N latitude summer sun
- Key result
- DT50:
- 2 d
- Test condition:
- Natural water
- Transformation products:
- yes
- Remarks:
- DE-535-acid and three degradates (DE-535-furan, DE-535-acid-phenone, DE-535-acid-furan) exceeding 10% of applied radiocarbon were observed.
- Conclusions:
- In pH 5 buffer, the expected half-life for the test substance was 20 and DT90 value was 66 days. Degradation was faster in natural water with DT50 value of 2 days and DT90 value of 7 days. The quantum yield value was 3.8E-3. Results indicate that in aqueous environments it is likely that the test substance will be photodegraded to form small naturally occurring organic acids and CO2.
- Executive summary:
This study determined the rate and route of photodegradation of the test substance in sterile pH 5 buffer and non-sterile natural water. The study was conducted following EPA guideline 161-2. 14C-test substance, radiolabeled either uniformly in the phenyl ring or in the 3,4-positions of the pyridine ring was applied to buffer and natural water to give a concentration of 2.0 µg/mL test substance and 0.8% acetonitrile co-solvent. Because test substance was quickly photolyzed to form DE-535-acid in natural water, the natural water samples were also used to calculate DT50 and DT90 values for DE-535-acid photolysis in natural water. 14C DE-535-acid, radio labeled either uniformly in the phenyl ring or in the 4,5-positions of the pyridine ring was applied only to buffer to give a concentration of 1.0 µg/mL DE-535-acid and less than 0.4% acetonitrile co-solvent.
Samples were continuously irradiated using a xenon arc lamp to simulate average summer sunlight at 40 °N latitude. Irradiated samples and dark controls for test substance and DE-535-acid were collected for buffer and natural water samples at 0, 0.8, 1.8, 4.8, 6.8, 8.8, 15.8, and 16.7 days after treatment (DAT) and analyzed by reverse phase high pressure liquid chromatography (HPLC). Additional sampling times for the DE-535 in natural water were collected at 0, 0.04, 0.3, 0.1, 0.8, and 1.8 DAT.
In pH 5 buffer, the expected half-lives for the test substance and DE-535-acid at 40° N latitude summer sun were 20 and 12 days, respectively, and DT90 values were 66 days (test substance) and 40 days (DE-535-acid). Degradation was faster in natural water with DT50 values of 2 days (test substance) and 8 days (DE-535-acid) and DT90 values of 7 days (test substance) and 24 days (DE-535-acid). The quantum yield values were 3.8E-3 for test substance and 1.7E-2 for DE-535-acid.
Reference
Description of key information
Study Type |
Study Details | Value | Guideline | Reliability |
Phototransformation in water | pH 5 buffer and natural water |
DT50 = 20 and 2 days |
EPA 161-2 |
1 |
Key value for chemical safety assessment
- Half-life in water:
- 2 d
Additional information
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