Registration Dossier

Administrative data

Description of key information

Hazards identified by EU Assessment in May 2008:
"There is an extensive database in animals, indicating that TCPP is non-irritant in the rabbit eye and skin. The lack of any substantial skin or eye irritation and the lack of irritation observed in the acute inhalation studies suggest that TCPP would be unlikely to produce significant respiratory tract irritation."
Additional information:
TCPP was tested on 8 volunteers. 50 µl on a cotton pad was fixed on the arm by a tape. During the 7 days observation time the treated skin of the 8 volunteers remained unmodified. The substance was not irritating (Kimmerle G., 1973).

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Justification for classification or non-classification

EU Risk Assessment of 2008: "Based on the available studies, TCPP needs no classification for irritation according to EU guidelines."

Update March 2018: The conclusion of non-classification for irritation is confirmed and compliant with EU Regulation 1272/2008.