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EC number: 947-570-5
CAS number: -
Table 7.10.4/2: Individual scores following Patch Application of
Group 90, BP-10-11
M: applied to an adjacent site after strong test reaction
-: panelist absent
*: residual reaction to earlier application, after an absence, not
included in score totals
Table 7.10.4/3: Score Totals for All Panelists Following Application
of Group 90, BP-10-11
NP: number of panelists not included in score total: (-, *)
Table 7.10.4/4: Individual scores following Patch Application of
Group 90, BP-10-11L
( ): scores un ( ) are residual or flaring reactions on sites of earlier
applications, recorded only when of special interest. Not included in
Table 7.10.4/5: Score Totals for All Panelists Following Application
of Group 90, BP-10-11L
In a Human Repeated Insult Patch Test, the primary irritation and
sensitization propoerties of the test sample was tested on 22 volunteers.
The procedure used was an adaptation of the method of Draize. Before
application to the skin, 0.5 mL of the sample was applied to the Webril
swatch by means of a calibrated dropper. The test patches were applied
to the upper arms of the panelists, 3 times per week for 3 weeks. Eight
different samples from the group number 90 were tested simultaneously on
each panelist. The order of application was varied so that each test
material occupied each of the possible positions with approximately
equal frequency. The panelists were instructed to remove the patches 24
hours after application.
Each patch was applied to the same area each time unless the severity of
a reaction made this inadvisable. In such cases, subsequent application
was made to an adjacent site or omitted. For the final challenge
application after a 2-week rest period, duplicate patches were applied,
one to the original site and one to a skin which had not previously
received any patches.
Reactions to the test material were scored after removal of each patch.
- group 90, BP-10-11: twenty-two panelists showed little or no primary
irritation. Two panelists, Nos. 1 and 5, showed evidence of possible
- group 90, BP-10-11L: Twenty-one panelists showed little or no
reaction. Panelists, No.5, showed moderate primary irritation. No
evidence of sensitization was exhibited by the panelists.
Under the test conditions, the test material tested undiluted can be
considered as non-sensitizing.
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