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Diss Factsheets
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EC number: 235-546-0 | CAS number: 12270-13-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- For justification of read-across please refer to the read-across report attached to IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Type:
- log Pow
- Partition coefficient:
- -1.6
- Temp.:
- 20 °C
- Remarks on result:
- other: pH not reported
- Conclusions:
- The partition coefficient (n-octanol/water) of the test item was estimated based on the ratio of the individual solubilities of the test item in water and n-octanol. The solubilities were determined according to the flask method.
It was found to be: log Pow = -1.6 - Executive summary:
The partition coefficient (n-octanol/water) was determined using the flask method according to OECD 107. As the water solubility was determined to be 46 g/L in an other experiment, only the n-octanol solubility needed to be measured.
The quantity of test item necessary to saturate the desired volume of n-octanol is estimated from the preliminary test. About five times that quantity is weighed into each of three glass vessels fitted with glass stoppers. The batches are stirred for different times at 30 °C (24 h experiment, 48 h experiment, 72 h experiment) in tightly closed flasks.Another experiment is performed according to this procedure but without test item (“blank”). After equilibration (further stirring for 24 h at 20 °C) the suspensions are taken and prepared for the analytical determination via HPLC. The n-octanol solubility of the test item at 20 °C was determined to be 1.15 g/L (± 0.08 g/L). The water solubility of the test item at 20 °C was determined to be 46 g/L (± 3 g/L)in a seperate experimient.
The partition coefficient POWof the test item was determined to be: 0.025, wherefore the log POW was calculated to be -1.6.
This information is used in a read-across approach in the assessment of the target substance.
For justification of read-across please refer to the attached read-across report (see IUCLID section 13).
Reference
Description of key information
The partition coefficient (n-octanol/water) was determined using the flask method according to OECD 107. As the water solubility was determined to be 46 g/L in another experiment, only the n-octanol solubility needed to be measured.
The n-octanol solubility of the test item at 20 °C was determined to be 1.15 g/L (± 0.08 g/L). The water solubility of the test item at 20 °C was determined to be 46 g/L (± 3 g/L) in a separate experiment.
The partition coefficient POW of the test item was determined to be: 0.025, wherefore the log POW was calculated to be -1.6.
This information is used in a read-across approach in the assessment of the target substance.
For justification of read-across please refer to the attached read-across report (see IUCLID section 13).
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -1.6
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.