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Physical & Chemical properties

Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
11 February 2013 to 19 February 2013
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
GLP compliance:
yes (incl. certificate)
Type of method:
effusion method: vapour pressure balance
Key result
Temp.:
25 °C
Vapour pressure:
0 Pa

A total of seven runs were completed for the main sequence. Equilibrium with regard to vapour pressure was assessed to have been reached over the final six runs. Thus, the final six runs have been used to calculate the definitive vapour pressure value for the test item. The values of vapour pressure at 25°C extrapolated from each graph are summarized in the following table:

Run

Log10[Vp(25ºC)]

2

-3.79

3

-3.82

4

-3.87

5

-3.79

6

-3.82

7

-3.85

Mean

-3.82

Vapor Pressure

1.50 x 10-4Pa

The test item did not change in appearance under the conditions used in the determination.

Conclusions:
The vapour pressure of the substance as a 50% w.w. concentration in pharmaceutical white oil has been determined to be 0.00015 Pa at 25°C.
Executive summary:

The vapour pressure of the substance as a 50% w.w. concentration in pharmaceutical white oil has been determined to be 0.00015 Pa at 25°C.The vapour pressure of the test item was determined in a GLP-compliant vapour pressure balance test (Harlan 2013) following OECD guideline 104. The study is considered reliable and relevant for use for this endpoint.

Description of key information

The vapour pressure of the substance as a 50% w.w. concentration in pharmaceutical white oil has been determined to be 0.00015 Pa at 25°C.

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
25 °C

Additional information

The vapour pressure of the test item was determined in a GLP-compliant vapour pressure balance test (Harlan 2013) following OECD guideline 104