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EC number: 223-296-5
CAS number: 3811-73-2
See Tables 18.104.22.168, 22.214.171.124, 126.96.36.199, and 188.8.131.52 for
summaries on the acute toxicity to invertebrates of sodium pyrithione
and its metabolites.
on invertebrates indicate that NaPT is toxic. The LC50values
range from 0.022 to 0.15 mg NaPT/L.The lowest NOEC for these
studies was 0.011 mg NaPT/L.
acute toxicity studies in fish for the major metabolites indicate that
the most toxic substance is Pyrithione disulphide with a NOEC of 0.006
mg/L, to daphnia magna. Pyrithione
disulphide is very short lived in the environment and the most relevant
degradant of NaPT is Pyridine sulphonic acid (PSA). The NOEC for PSA is
51.1 for the eastern oyster.
Table 184.108.40.206: Acute
toxicity of NaPT to invertebrates
Guideline /Test method
Endpoint /Type of test
OECD 202.92/69/EEC, C.2.
Smith et al (1994)
U.S. EPA-FIFRA, Guideline 72-2
Table 220.127.116.11: Acute
toxicity of Pyridine-N-oxide-2-sulfonic acid to invertebrates
Immobility and mortality
Ward TJ, Kowalski PL, Boeri RL (1994)
US EPA – 72-3(b)
Ward TJ, Kowalski PL, Boeri RL (1994
eastern oysterCrassostrea virginica
Boeri RL, Kowalski PL, Ward TJ (1994)
Table 18.104.22.168: Acute
toxicity of Pyridine Sulphonic acid to invertebrates
Table 22.214.171.124: Acute
toxicity of 2,2’-(pyridyl-N-oxide) disulphide to invertebrates
Ward TJ, Magazu JP, Boeri RL (1995)
US EPA- 72-3(b)
US EPA – 72-3(c)
contained within this robust summary document comes from studies which
are in the ownership of Arch Chemicals Inc. and which are protected in
several regions globally. This information may not be used for any
purpose other than in support of the Chemical safety Report submitted by
Arch Chemicals Inc. under RegulationEC
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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