(Z)-9-Octadecen-1-ol ethoxylated

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2 Dec 2019 - 15 Jan 2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

no

Type of method:

column elution method

Water solubility:

< 40 µg/L

Temp.:

20 °C

pH:

6.2

Remarks on result:

other: below the detection limit of the analytical method

Preliminary test:

Experiment	Water [mL]	Test Item [mg]	Result
A	2.0	96.5	Hazy mixture
B	8.0	51.3	Hazy mixture
C	8.0	4.9	Hazy mixture
D	25	2.9	Hazy mixture
E	100	6.4	Hazy mixture

Based on these results, the column elution method was considered suitable for the determination of the water solubility of the test item.

Main test results

The concentrations of the test item in different test solutions were calculated automatically using the equation of the calibration curve. The results are shown in the following table (pH = 6.2):

Flow rate (mL/h)	Fraction No. (combined aliquots)	Concentration of the test item (µg/L)
25.0	1(1-2)	< 40
	2(3-4)	< 40
	3(5-6)	< 40
	4(7-8)	< 40
	5(9-10)	< 40
	6(11-12)	< 40
	7(13-14)	< 40
	8(15-16)	< 40
12.5	1(1-2)	< 40
	2(3-4)	< 40
	3(5-6)	< 40
	4(7-8)	82.5
	5(9-10)	< 40
	6(11-12)	< 40
	7(13-14)	< 40
	8(15-16)	< 40

In most of the fractions, the concentration of the test item is below the detection limit of the analytical method. In one fraction, where the test item was detected, it was likely due to droplets breaking through the column. For this reason, this value was not considered as valid result.

Reference 2

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

no

Type of method:

flask method

Water solubility:

< 1 g/L

Temp.:

20 °C

pH:

3.8

Remarks on result:

other: The test substance forms emulsions at concentrations below 1,00 g/L in MilliQ water

Details on results:

Measurement not applicable: The test substance forms emulsions at concentrations below 1,00 g/L in MilliQ water at 20°C and pH= 3.8

Measurement:

Temperature: 20 °C

pH: 3.8

Equilibration time for solubilization: 1 week

Sample volume: 0.1 ml

Volume of water: 100 ml

Conclusions:

Interpretation of results (migrated information): moderately soluble (100-1000 mg/L) the substance gives origin to emulsions at the concentration of 1g/L at 20°C and pH=3.8

Executive summary:

The substance (Z)-9 -Octadecen-1 -ol ethoxylated gives origin to emulsions at the concentration of and below 1 g/L at 20°C and pH=3.8

Description of key information

The water solubility of the substance is  < 0.40 µg/L at 20 °C, pH 6.2. 

Key value for chemical safety assessment

Water solubility:

0.4 µg/L

at the temperature of:

25 °C

Additional information

The water solubility has been measured using column elution method (OECD 105). In an older study the water solubility was measured to be < 1 g/L, what was not precise because of the emulsion formation, but in principle supporting.